Study on intravenous fluids in dengue shock
- Conditions
- Health Condition 1: A91- Dengue hemorrhagic fever
- Registration Number
- CTRI/2023/11/060213
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Children suffering from dengue shock syndrome (DSS) will be enrolled.
DSS will be defined as DHF as well as hypotension, tachycardia, narrow pulse pressure (less than/equal to 20 mmHg) and signs of poor perfusion (e.g cold extremities, delayed capillary filling time, feeble pulses).
Dengue Haemorrhagic Fever (DHF) will be defined as a child fulfilling clinical criteria of dengue fever with bleeding tendencies viz., petechiae, ecchymoses or purpura, positive tourniquet test and/or skin, mucosal or gastrointestinal bleed with thrombocytopenia ( <100000 cells per mm3) with increased vascular permeability (viz. > 20% increase in haematocrit, >20% decrease in haematocrit after fluid therapy, pleural effusion, ascites, hypoproteinemia).
1)Children already received fluids from outside before enrolment in last 6 h
2)Children with cardiogenic shock
3)Known patient with chronic kidney disease as per KDIGO.
4)Severe malnutrition defined as per WHO.
5)Children whose parents deny consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method = 5mmol/L increase in serum chloride level within 48 hours (h) post-randomization.Timepoint: Baseline, 48 hours
- Secondary Outcome Measures
Name Time Method hospital stay duration, need for colloid bolus, incidence of hyponatremia (serum sodium less than 135 mmol/L in the first 48 h of fluid management), new-onset AKI, standard base excess, serum lactate levels, renal replacement therapy, organ dysfunction (25)and serum magnesium levels.Timepoint: first 48 hours, during hospital stay