NCT01244542终止不适用
Pain and Schizophrenia
University Hospital, Strasbourg, France10 个研究点 分布在 1 个国家目标入组 83 人开始时间: 2011年8月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 83
- 试验地点
- 10
- 主要终点
- Unpleasant stimuli
研究概览
简要总结
The aim of the investigators project is to explore the mechanisms of pain insensitivity in patients with schizophrenia, in order to prevent its invalidating consequences. The investigators will couple methods of experimental psychology with EEG and blood samplings, in order to distinguish the role of non-painful perception, attention, aversive effects, and pain expression, and the investigators will explore an original neurobiological hypothesis regarding the activation of opioid receptors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with schizophrenia (criteria DSM IV) or healthy controls matched with patients on age, sex and education level
- •18-55 years old
排除标准
- •Past history affecting CNS
- •Intake of psychotropic drugs, except for patients
- •Metabolic disorder affecting sensory processing (diabetes)
- •Intake of benzodiazepines
研究组 & 干预措施
Patients with schizophrenia
Experimental
干预措施: unpleasant stimuli (Other)
Healthy controls
Active Comparator
controls matched with patients on age, sex and education level
干预措施: unpleasant stimuli (Other)
结局指标
主要结局
Unpleasant stimuli
时间窗: during experimental session
acute electrical stimulation
次要结局
未报告次要终点
研究者
研究点 (10)
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