A Multi-Center, Open-Label, Phase Ib/II Clinical Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Sufatinib in Treating Advanced Neuroendocrine Tumors

Hutchison Medipharma Limited7 sites in 1 country81 target enrollmentOctober 31, 2014

ConditionsNeuroendocrine Tumors

InterventionsSulfatinib

DrugsSulfatinib

Overview

Phase: Phase 1
Intervention: Sulfatinib
Conditions: Neuroendocrine Tumors
Sponsor: Hutchison Medipharma Limited
Enrollment: 81
Locations: 7
Primary Endpoint: Incidence and severity of AE/SAEs
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

a multicenter, open-label phase Ib study to determine the safety, tolerability and preliminary efficacy of Sulfatinib 300 mg once a day in treating advanced neuroendocrine tumors

Detailed Description

The study population is patients with low- or intermediate-grade (G1 or G2) advanced NET who have failed in standard treatment or are unable to receive standard treatment.Sulfatinib 300 mg once a day (QD) will be orally administrated on a 28-day cycle. Investigators will evaluate the clinical tumor response to Sulfatinib, and if investigators determine that the patient can benefit from the continuation of treatment, the patient will continue the Sulfatinib treatment. The duration of study will be 2 years. At the time of study completion, if investigators believe patients can continue to benefit from the investigational product, patients may be provided with Sulfatinib with the agreement of the sponsor.

Registry

clinicaltrials.gov

Start Date

October 31, 2014

End Date

August 23, 2017

Last Updated

7 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Hutchison Medipharma Limited

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Fully understand the study and voluntarily sign the informed consent form;
•Be at least 18 years old;
•Have a confirmed histological or cytological diagnosis of low- or intermediate-grade advanced NETs (unresectable or metastatic), for which standard treatment has failed or cannot be received. The NETs must meet the following criteria: (a) be GEP-NETs or NETs with the primary lesion located in tissue other than the lung or thymus (including unknown primary lesion location), with a mitotic count of ≤ 20/10 High Power Field \[HPF\] and a Ki67 index of ≤ 20%; or (b) be NETs of the lung or thymus (carcinoid) with a mitotic count of ≤ 10/10 High Power Field \[HPF\])
•Have measurable lesions (according to RECIST 1.1);
•Have a performance status (PS) of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) scale;
•Have expected survival of more than 12 weeks;
•Female patients with reproductive potential must agree to use an effective contraceptive method, for example, double-barrier device, condom, oral or injection birth control medication or intrauterine device, during the study and for 90 days after study completion.

Exclusion Criteria

•Absolute neutrophil count (ANC) of \< 1.5×109/L, or platelet count of \< 100 ×109/L, or hemoglobin \< 9 g/dL;
•Serum total bilirubin \> 1.5 times the upper limit of normal (ULN);
•ALT, AST or ALP \> 2.5 ULN without hepatic metastases or ALT, AST or ALP \> 5 ULN with hepatic metastases
•Clinically significant serum potassium (regardless of potassium agent supplementation); serum calcium (ionic or binding to albumin post-adjusted) or clinically significant abnormal serum magnesium (regardless of magnesium agent supplementation);
•Serum creatinine \> 1.5 ULN (with the exception of CCR ≥ 60 ml/min based on 24-hour urine collection);
•Urine protein \> 2+, or 24-hour urine protein quantity \>1 gram;
•Uncontrolled hypertension, defined as: systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90mmHg;
•International Normalized Ratio (INR) \> 1.5 ULN or activated partial thromboplastin time (aPTT) \> 1.5 ULN. INR is only for patients not receiving anticoagulant therapy;
•History or presence of digestive tract diseases, including active gastric/duodenal ulcer or ulcerative colitis, or active hemorrhage of an unresected gastrointestinal tumor, or an evaluation by investigators of having any other condition that could possibly result in gastrointestinal tract hemorrhage or perforation;
•History or presence of serious hemorrhage (\> 30 ml within 3 months), hemoptysis (\> 5 ml fresh blood within 4 weeks) or a thromboembolic event (including transient ischemic attack) within 12 months;