Comparative evaluation of analgesic efficacy of intravenous ibuprofen, paracetamol and their combination in spine surgery
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To evaluate the analgesic efficacy of intravenous Ibuprofen and Paracetamol combination on postoperative pain by visual analogue scale.
研究概览
简要总结
Postoperative pain management in spine surgery remains a challenge, with opioids being the primary treatment but associated with significant side effects. Non-opioid alternatives like IV ibuprofen and paracetamol have shown promise in reducing pain and opioid consumption. However, limited research exists on their combined effectiveness.This study aims to compare the analgesic efficacy of IV ibuprofen, IV paracetamol, and their combination in spine surgery patients. The goal is to determine whether a combined approach provides superior pain relief, reduces opioid use, and improves patient outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grade 1-3
- •Age 18-60 years of both gender.
- •Patient scheduled for spine surgery.
排除标准
- •Patient with cardiac and pulmonary disease.
- •Patient with complicated diabetes and hypertension
- •Patient with deranged renal function test and liver function tests.
- •Patients sensitive to propofol, fentanyl, paracetamol, vecuronium, ibuprofen and morphine.
- •Difficulty in the usage of PCA.
结局指标
主要结局
To evaluate the analgesic efficacy of intravenous Ibuprofen and Paracetamol combination on postoperative pain by visual analogue scale.
时间窗: 24 hours
次要结局
- 1.To evaluate and compare the analgesic efficacy of intravenous Ibuprofen and Paracetamol on postoperative pain by visual analogue scale.(2. Postoperative morphine consumption and its side effects.)
研究者
Dr NIKHIL
School of medical sciences and research, Sharda Hospital