Thrombus Analysis of Ischemic Stroke

Recruiting

• Conditions: Cerebral Infarction

• Registration Number: NCT07043413
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Patients with acute ischemic stroke who have undergone endovascular thrombectomy will be eligible to be included, and thrombus will be collected after obtaining informed consent. Enrolled patients will receive a comprehensive diagnostic evaluation and the best medical treatment according to recent stroke management guidelines. The mechanism of the stroke will be classified into atherosclerotic, cardiac embolism, others and unknown causes based on diagnostic workup. Patients will be monitored in an outpatient clinic for vascular events including stroke recurrence, death, and bleeding events, which will continue for up to two years after the initial stroke event. Thrombus information related to RNA expression patterns and histological characteristics will be analyzed to classify the stroke mechanism and predict future vascular events after the initial stroke.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-25
• Status Verified: 2025-06
• Study First Submitted: 2025-06-20
• Study First Submitted QC: 2025-06-20
• Last Update Submitted: 2025-06-20
• Study First Posted: 2025-06-29
• Last Update Posted: 2025-06-29
• Primary Completion: 2028-12-31
• Study Completion: 2029-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• patients with acute ischemic stroke who had undergone endovascular thrombectomy

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vascular events	two years after initial stroke	major vascular events after endovascular thrombectomy, including stroke, myocardial infarction, and vascular death

Secondary Outcome Measures

Name	Time	Method
Thromboembolic events	two years after initial stroke	Any thromboembolic events after endovascular thrombectomy including ischemic stroke, transient ischemic attack, myocardial infarction or unstable angina, peripheral artery disease requiring hospitalization, venous thromboembolism, pulmonary embolism and vascular death

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Jong-ro Gu, Korea, Republic of