The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion: a prospective, randomized, controlled clinical trial
- Conditions
- malignant pleural effusion
- Registration Number
- ITMCTR2000003487
- Lead Sponsor
- onghua Hospital affiliated to Shanghai University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
(1) At least 1 imaging examination (X-ray, B-ultrasound) showed moderate or above malignant pleural effusion, and the time between imaging examination and inclusion was <= 2 weeks.
(2) Advanced malignant tumor with malignant pleural effusion confirmed by histopathology or cytology.
(3) The expected survival time is more than 3 months, and the age of 18 <= 80 years.
(4) Karnofsky score >= 60, ECOG PS score <= 2.
(5) No serious heart, kidney, liver diseases or other therapeutic contraindications.
(6) No chemotherapy or intrathoracic drug injection was performed within 1 month before the inclusion of treatment, except for diagnostic puncture.
(7) Sign informed consent and receive medical treatment.
(1) End-stage patients with cachexia and severe hypoproteinemia, unable to complete one course of treatment.
(2) Pregnant women, patients with mental disorders and those who do not cooperate with treatment.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method QLQ C30 scale;
- Secondary Outcome Measures
Name Time Method TCM syndrome score;Safety index;