Characteristics and In-hospital Outcomes of Chinese Elderly (>80 Years) Patients With Acute Ischemic Stroke Receiving Intravenous Recombinant Tissue Plasminogen Activator Treatment Within 4.5 Hours of Symptom Onset
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 113,035
- 试验地点
- 1
- 主要终点
- All-cause Mortality During Hospitalization of Acute Ischemic Stroke (AIS) Patients
研究概览
简要总结
The objective of the study is to find out the in-hospital clinical outcomes among Chinese Acute Ischaemic Stroke (AIS) patients, who were treated with intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) within 4.5 hours of symptom onset in different age groups (18 to 80 years and above 80 years).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient registered in the Chinese Stroke Centre Alliance (CSCA) platform from Aug 2015 to Jul 2019
- •≥18 years old
- •Diagnosed as Acute Ischemic Stroke (AIS) at admission
- •Arrived or admitted into hospital within 4.5 hours of symptom onset
- •For patients in the iv rt-PA groups only: received IV rt-PA within 4.5 hours of symptom onset
排除标准
- •Documented Intravenous Thrombolysis (IVT) absolute contraindication
- •Key data missing (age, gender, baseline National Institutes of Health Stroke Scale [NIHSS], time of symptom onset, IVT treated or not, time of IV alteplase treatment)
- •Received thrombolysis agents other than IV rt-PA (urokinase, tenecteplase, recombinant plasminogen activator, prourokinase, streptokinase)
- •Received endovascular treatment
- •Received IV rt-PA after 4.5 hours of symptom onset
研究组 & 干预措施
Acute ischemic stroke (AIS) patients aged >80 years who received IV rt-PA (Alteplase)
Group 1: Acute ischemic stroke (AIS) patients aged >80 years who received intravenous recombinant tissue plasminogen activator (IV rt-PA) (Alteplase) within 4.5 hours of symptom onset.
干预措施: rt-PA (Drug)
Acute ischemic stroke (AIS) patients aged 18 to 80 years who received IV rt-PA (Alteplase)
Group 2: Acute ischemic stroke (AIS) patients aged 18 to 80 years who received intravenous recombinant tissue plasminogen activator (IV rt-PA) (Alteplase) within 4.5 hours of symptom onset.
干预措施: rt-PA (Drug)
结局指标
主要结局
All-cause Mortality During Hospitalization of Acute Ischemic Stroke (AIS) Patients
时间窗: Up to 100 days.
All-cause mortality during hospitalization of acute ischemic stroke (AIS) patients who received intravenous recombinant tissue plasminogen activator (IV rt-PA).
次要结局
- Percentage of Patients With Hemorrhagic Stroke During Hospitalization(Up to 100 days.)
- Change of NIHSS Score From Before Intravenous Recombinant Tissue Plasminogen Activator (IV Rt-PA) Treatment to 24 Hours After IV Rt-PA Treatment(Up to 24 hours.)
- Modified Rankin Score (mRS) at Discharge(Up to 100 days.)
- Number of Patients With Stroke Recurrence During Hospitalization(Up to 100 days.)
- Length of Hospitalization(Up to 100 days.)
- Percentage of Intravenous Recombinant Tissue Plasminogen Activator (IV Rt-PA) Treatment Among Acute Ischemic Stroke (AIS) Patients Arrived or Were Admitted to the Hospital Within 4.5 Hours of Symptom Onset(Up to 4.5 hours.)
- Percentage of Intravenous Recombinant Tissue Plasminogen Activator (IV Rt-PA) Treatment Within 4.5 Hours of Symptom Onset Among Eligible AIS Patients (3.5-hour Arrival or Admission)(Up to 4.5 hours.)