Comparison of pain reief with two different doses of the drug dexmedetomidine used in nerve block following one sided knee replacement surgery.

Phase 2

Not yet recruiting

• Conditions: Unilateral primary osteoarthritisof knee,

• Registration Number: CTRI/2019/05/019307
• Lead Sponsor: Department Funds

Brief Summary

Total knee replacement surgery is a commonly performed orthopaedic surgery in the elderly age. Total knee replacement surgery causes immense post-operative pain. Multimodal analgesia is opted to facilitate pain relief , early ambulation and rehabilitation. Adductor canal block(ACB) is currently practised for post-operative pain relief following TKR. Studies have shown that adductor canal block provides better analgesia and superior quadriceps strength compared with femoral nerve block . Adductor canal block predominantly affects the 2 sensory branches of femoral nerve namely the saphenous nerve and the nerve to vastus medialis and part of articular branches of obturator nerve. ACB minimally affects the quadriceps muscles thus helping in early ambulation and rehabilitation.

Ropivacaine is a long-acting amide local anaesthetic agent. Ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity. Alpha 2 adrenergic agonists have both analgesic and sedative properties when used as an adjuvant in regional anaesthesia. Dexmedetomidine is a highly selective α2-adrenoreceptor agonist with sedative and analgesic effects. It enhances local anaesthetic effect without producing side effects, which makes it a good adjuvant to local anaesthetics. When compared to other sedatives, it produces sedation without significant respiratory compromise even at high doses.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-06
• Last Update Posted: 2019-05-22

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1.Patient aged 18-85 years 2.ASA I , II & III.

Exclusion Criteria

1)Patients refusal 2)Allergic to local anaesthetic 3)Patient on B Blockers and a agonist 4)Previously operated knee surgery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the analgesic efficacy of dexmedetomidine 0.5mcg/kg versus 1mcg/kg as an adjuvant to 0.2% ropivacaine in adductor canal block in patients undergoing unilateral total knee replacement surgery	Pain Score Post-operatively every 30 min for 2 hours and 4th hourly for 24 hours

Secondary Outcome Measures

Name	Time	Method
1)To assess the duration of analgesia.	2)To compare motor blockade postoperatively.

Trial Locations

Locations (1)

Amrita hospital; 🇮🇳 Ernakulam, KERALA, India

Amrita hospital

🇮🇳Ernakulam, KERALA, India

Dr Gokul das

Principal investigator

9847448005

gokuldas75@hotmail.com