Dietary Wild Blueberries and Joint Health

Not Applicable

Not yet recruiting

• Conditions: Gut -Microbiota; Inflammation Biomarkers; Pain Assessment; Joint Pain
• Interventions: Drug: Wild blueberry; Dietary Supplement: Placebo

• Registration Number: NCT06828159
• Lead Sponsor: University of Nevada, Las Vegas

Brief Summary

The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-02-10
• Study First Submitted QC: 2025-02-10
• Study First Posted: 2025-02-14
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-13
• Last Update Posted: 2025-05-15
• Study Start: 2025-07
• Primary Completion: 2027-12
• Study Completion: 2028-03

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Adults with documented multi-joint/knee arthritis

Exclusion Criteria

• inability to give informed consent
• pregnancy or lactation
• planned knee replacement surgery
• allergy or contraindication to berries
• recent trauma of the knee responsible of the symptomatic knee
• intra-articular injection in the target knee/hip in the last 3 months
• oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
• use of berry extracts in the last 3 months
• special diets
• cancer treatment
• bone diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Wild blueberries	Wild blueberry	25g freeze-dried wild blueberries daily for 12 weeks
Placebo	Placebo	Placebo powder free from polyphenols matched for calories

Primary Outcome Measures

Name	Time	Method
Serum biomarkers of joint function	12 weeks	Serum biomarkers of inflammation and cartilage degradation will be measured in the wild blueberry and placebo groups and compared for outcomes. Pain scores will also be measured using self-reported questionnaires.

Secondary Outcome Measures

Name	Time	Method
Gut microbiome	12 weeks