The Burden of (Neuro)Cysticercosis Among People Living With HIV Compared With HIV-negative Individuals in the Rural Southern Highlands in Tanzania
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,584
- 试验地点
- 1
- 主要终点
- Prevalence of cysticercosis
研究概览
简要总结
This study aims to compare the burden of neurocysticercosis among people living with HIV to people not infected with HIV.
详细描述
People living with HIV and matched HIV negative controls will be tested serologically for cysticercosis, examined neurologically and will undergo CT scanning to determine the prevalence and presentation of NCC.
Furthermore, the immune system response in HIV patients with Taenia solium neurocysticercosis will be assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 14 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who consent to participate in the study and testing.
- •Patients of age 14 years and above
- •Patient living inside the study catchment area
- •HIV-positive patients
- •Patient suspected of taeniasis or cysticercosis/neurocysticercosis
排除标准
- •Patients with opportunistic infections.
- •Study participants taking anthelminthic drugs PZQ and ALB or have received them within the previous 12 months.
- •Pregnant women
- •Patients that are seriously ill.
- •Patients with epilepsy and other mental disorders that impair thoughts and emotions such as psychosis.
结局指标
主要结局
Prevalence of cysticercosis
时间窗: Single assessment at inclusion into study (serological testing)
Prevalence of cysticercosis among people living with HIV and matched HIV-negative individuals in rural Tanzania where pig farming is common
Prevalence of neurocysticercosis
时间窗: Single assessment through cerebral CT scan at inclusion into study
Prevalence of neurocysticercosis among people living with HIV and matched HIV-negative individuals in rural Tanzania where pig farming is common
次要结局
- Th1 cytokines among neurocysticercosis patients(One time assessment through immunological testing at inclusion into study)