DRKS00000065
尚未招募
不适用
Modification of leukocyte activation status during sepsis-induced acute renal failure.
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin Universitätsklinikum Münster0 个研究点目标入组 60 人2009年1月12日
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Sepsisacute renal failure
- 发起方
- Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin Universitätsklinikum Münster
- 入组人数
- 60
- 状态
- 尚未招募
- 最后更新
- 去年
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •sepsis (Anonymous, Crit Care Med 1992, 20:864\-874\):
- •1\. At least two oft he following parameters:
- •a) hypothermia (core temperature \<36°C) or fever (\>38\.3°C)
- •b) tachycardia with heart rate \> 90 beats per minute
- •c) tachypnea wit \>\= 20 breaths per minute and/or paCO2 \<\= 32 mmHg or mechanical ventilation d) leucopenia (WBC \< 4,000 cells/µl) or leukocytosis (WBC count \>12,000 cells/µl) or normal WBC count with \> 10 % immature forms
- •2\. Infection, documented or suspected,
- •acute renal failure (RIFLE, Bellomo, Critical Care 2004, 8:R204\-R212\):
- •1\. increase of serumcreatinine x 3 compared to initial value (e.g. within the last 7 days)
- •2\. urine output \< 0,3 ml/kg/h for 24 hours or anuria for 12 hours
排除标准
- •age \< 18 years
- •immunsupressive therapy (within the last 7 days)
- •chronic renal failure (eGFR \< 60 l/min)
- •known haematologic disease
- •known HIV\-infection
结局指标
主要结局
未指定
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