DRKS00000065尚未招募不适用
Modification of leukocyte activation status during sepsis-induced acute renal failure.
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin Universitätsklinikum Münster0 个研究点目标入组 60 人开始时间: 2009年1月12日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •sepsis (Anonymous, Crit Care Med 1992, 20:864-874):
- •1. At least two oft he following parameters:
- •a) hypothermia (core temperature <36°C) or fever (>38.3°C)
- •b) tachycardia with heart rate > 90 beats per minute
- •c) tachypnea wit >= 20 breaths per minute and/or paCO2 <= 32 mmHg or mechanical ventilation d) leucopenia (WBC < 4,000 cells/µl) or leukocytosis (WBC count >12,000 cells/µl) or normal WBC count with > 10 % immature forms
- •2. Infection, documented or suspected,
- •acute renal failure (RIFLE, Bellomo, Critical Care 2004, 8:R204-R212):
- •1. increase of serumcreatinine x 3 compared to initial value (e.g. within the last 7 days)
- •2. urine output < 0,3 ml/kg/h for 24 hours or anuria for 12 hours
排除标准
- •age < 18 years
- •immunsupressive therapy (within the last 7 days)
- •chronic renal failure (eGFR < 60 l/min)
- •known haematologic disease
- •known HIV-infection
研究者
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