Modification of leukocyte activation status during sepsis-induced acute renal failure.

• Conditions: Sepsisacute renal failure; N17; A41.9; Acute renal failure; Sepsis, unspecified

• Registration Number: DRKS00000065
• Lead Sponsor: Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin Universitätsklinikum Münster

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

sepsis (Anonymous, Crit Care Med 1992, 20:864-874):
1. At least two oft he following parameters:
a) hypothermia (core temperature <36°C) or fever (>38.3°C)
b) tachycardia with heart rate > 90 beats per minute
c) tachypnea wit >= 20 breaths per minute and/or paCO2 <= 32 mmHg or mechanical ventilation d) leucopenia (WBC < 4,000 cells/µl) or leukocytosis (WBC count >12,000 cells/µl) or normal WBC count with > 10 % immature forms
AND
2. Infection, documented or suspected,

acute renal failure (RIFLE, Bellomo, Critical Care 2004, 8:R204-R212):
1. increase of serumcreatinine x 3 compared to initial value (e.g. within the last 7 days)
OR
2. urine output < 0,3 ml/kg/h for 24 hours or anuria for 12 hours

Exclusion Criteria

age < 18 years
gravidity
immunsupressive therapy (within the last 7 days)
chronic renal failure (eGFR < 60 l/min)
known haematologic disease
known HIV-infection

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
analysis of neutrophil activation status via flow chamber and flow cytometry after asservation of samples