NCT04446897CompletedPhase 1
Treatment of Chronic Medium-severe Periodontitis With Mesenchymal Stem Cells Predifferentiated in Osteogenic Direction Immobilised on a Biodegradable Carrier
Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus2 sites in 1 country10 target enrollmentStarted: August 3, 2020Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Enrollment
- 10
- Locations
- 2
- Primary Endpoint
- number of patients cured
Study Overview
Brief Summary
Treatment of chronic medium-severe periodontitis with mesenchymal stem cells and mesenchymal stem cells predifferentiated in osteogenic direction
Detailed Description
The bone defect will be filled with a porous membrane based on bone collagen measuring 5x5 mm or more with mesenchymal stem cells and mesenchymal stem cells predifferentiated in osteogenic direction
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 70 Years to 70 Years (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •chronic medium-severe periodontitis
Exclusion Criteria
- •pregnancy
- •breast-feeding
- •acute and chronic infectious diseases: HIV, viral hepatitis, tuberculosis
- •mental disorders
Arms & Interventions
mesenchymal stem cells
Experimental
standard treatment according to clinical protocols plus mesenchymal stem cells
Intervention: mesenchymal stem cells (Biological)
Outcomes
Primary Outcomes
number of patients cured
Time Frame: 1 month
number of patients cured
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (2)
Loading locations...
Similar Trials
Completed
Phase 1
Clinical Trials of Regeneration for Periodontal TissueAdult PeriodontitisNCT00221130Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan10
Completed
Early Phase 1
Treatment of gum diseaseChronic periodontitis.Gingivitis and periodontal diseasesIRCT2013110215236N1aser Department, Dental School of Tehran University of Medical Sciences44
Not yet recruiting
Not Applicable
Effect of Internal and External Micro-needling in Treatment of Stage III PeriodontitisPeriodontal DiseasesNCT06578403Misr University for Science and Technology66
Completed
Phase 4
Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive CareChronic PeriodontitisNCT01195493University Hospital, Ghent50
Terminated
Not Applicable
Chronic Periodontitis and Tooth Loss in Patients With Rheumatoid ArthritisRheumatoid ArthritisPeriodontitisNCT02441920University of Birmingham400