Prevalence of Clopidogrel (Plavix) Resistance in Hemodialysis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Prevalence Of Plavix resistance
研究概览
简要总结
The investigators are trying to find out if Clopidogrel (Plavix) is as effective in hemodialysis patients as in patients not hemodialysed.
详细描述
Cardiovascular disease is very frequent in hemodialysis patients. Lot of hemodialysis patients are on Clopidogrel (plavix). Their is some evidence that clopidogrel is not effective in hemodialysis as it is effective in patient without kidney problem.
VerifyNow plavix is a machine that measure the ability of the blood to clot after giving plavix.
We will collect blood from hemodialysis patients on plavix and check the ability of their blood to clot and thus indirectly measuring the efficacy of Plavix.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients on hemodialysis taking Plavix
排除标准
- •known to have bleeding disorder
- •Severely anemic with hemoglobin level (Hb) < 10g/dl
- •Low Platelets < 10000
结局指标
主要结局
Prevalence Of Plavix resistance
时间窗: 1 day ( one study visit)
Plavix resistance is reported using the PRU values given by the VerifyNow machine. PRU is P2Y12 Reaction Units which is correlated with platelet aggregation.
次要结局
- assess the risk factors for plavix resistance in the hemodialysis population(1 day (one study visit))
研究者
Suzanne El-Sayegh
Nephrology Attending, Assoc. Chair of Medicine
Northwell Health