Typical Daily Experiences, Ischemia and Repolarization in Coronary Artery Disease

Completed

• Conditions: Coronary Artery Disease; Behavioral

• Registration Number: NCT01531231
• Lead Sponsor: Richard Lane

Brief Summary

The purpose of this study is to examine the role of every day experiences as they relate to coronary artery disease (CAD).

Detailed Description

CAD is the most common setting in which sudden cardiac death (SCD) occurs. SCD is the leading cause of death in the U.S.

In this study we propose to test the following in patients with CAD:

* Determine whether experiences assessed randomly throughout the day are associated with changes in the blood supply to your heart muscle as measured by electrical recordings from your chest.

* Determine whether typical daily experiences are associated with changes in the recovery time portion of your heart beat cycle as measured by electrical recordings from your chest.

* Determine whether changes in the recovery time portion of your heart beat cycle associated with typical daily experiences occur exclusively with changes in the blood supply to your heart muscle.

* Determine whether typical daily experiences influences blood supply and recovery time based on the severity and presence of CAD (when comparing CAD patients to healthy subjects).

Study Timeline

• Study Start: 2011-06-02
• Study First Submitted: 2012-02-08
• Study First Submitted QC: 2012-02-08
• Study First Posted: 2012-02-10
• Primary Completion: 2016-03-24
• Study Completion: 2016-03-29
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-27
• Last Update Posted: 2024-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 301

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To obtain behavioral and cardiovascular data including 4-days collection of data as study participant engages in their daily activities.	4 days	To determine whether typical daily emotion is associated with myocardial ischemia and repolarization changes in patients with coronary artery disease, and then determine whether the association between repolarization changes and daily emotion is related to myocardial ischemia; whether daily emotion influences ischemia and repolarization differentially as a function of severity of coronary artery disease; whether the association between daily emotion and repolarization varies in healthy volunteers. Some of these outcomes are intertwined.

Trial Locations

Locations (1)

University of Arizona; 🇺🇸 Tucson, Arizona, United States