Physical Therapy vs Arthroscopic Partial Meniscectomy on the Knee Function of Metabolic Syndrome Patients With Degenerative Meniscus Lesions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Knee Medial Meniscus Tears
- Sponsor
- Shenzhen People's Hospital
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- the Knee Injury and Osteoarthritis Outcome Score (KOOS) change
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose was to assess knee function outcomes between physical therapy and arthroscopic partial menisectomy(APM) for Metabolic syndrome(MetS) patients with degenerative meniscus lesions(DMLs) during 12 month follow up.
Detailed Description
Metabolic syndrome were diagnosed with abdominal obesity, insulin resistance with or without glucose intolerance, dyslipidemia or elevated blood pressure and widely prevalence all around the world.MetS patients were always correlated with knee osteoarthritis or cartilage volume loss. For MetS patients with DMLs, whether physical therapy was non-inferior to APM in knee function and MetS components was unknown.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Must be age between 35 and 70 years old;
- •Clinical diagnosis of metabolic syndrome;
- •Clinical diagnosis of degenerative meniscus lesions;
- •Patients who has knee pain history
- •Knee symptoms consistent with DMLs verified on MRI
- •eligible for arthroscopic partial meniscectomy surgery by the examining orthopedic surgeons.
Exclusion Criteria
- •Must be able to have no acute knee injury such as car crash or acute sports injury;
- •Must be able to have no knee surgeries history;
- •Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity;
- •Must be able to have no contraindications to MRI;
- •Must be able to have no severe cardiopulmonary disease;
- •Must be able to have no musculoskeletal or neuromuscular impairments ;
- •Must be able to have good visual, hearing, or cognitive;
Outcomes
Primary Outcomes
the Knee Injury and Osteoarthritis Outcome Score (KOOS) change
Time Frame: change from baseline up to 12 months
The Knee injury and Osteoarthritis Outcome Score (KOOS) holds five subscales including: Pain (9 items); other Symptoms (7 items); Activities of Daily Living (ADL, 17 items); Sport and Recreation function (Sport/Rec, 5 items); and knee-related Quality of Life (QoL, 4 items). Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems)
systolic blood pressure change
Time Frame: change from baseline up to 12 months
systolic blood pressure /mmHg
Kellgren-Lawrence (K/L) grade change
Time Frame: change from baseline up to 12 months
Kellgren-Lawrence (K/L) grade
high-density lipoprotein cholesterol (HDL-C) change
Time Frame: change from baseline up to 12 months
serum high-density lipoprotein cholesterol (HDL-C) (mmol/L)
fast blood glucose(FBG) change
Time Frame: change from baseline up to 12 months
serum fast blood glucose(FBG) (mmol/L)
serum triglycerides (TG) change
Time Frame: change from baseline up to 12 months
serum triglycerides (TG) (mmol/L)
low-density lipoprotein cholesterol (LDL-C) change
Time Frame: change from baseline up to 12 months
serum low-density lipoprotein cholesterol (LDL-C) (mmol/L)
the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC Score) change
Time Frame: change from baseline up to 12 months
The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score questionnaire contains 18 items (7 items for symptoms, 1 item for sport activity, 9 items for daily activities, and 1 item for current knee function.) The total score is transformed to a value on a scale of 0 to 100, with 100 representing the highest knee function and 0 is the worst.
waist circumstance change
Time Frame: change from baseline up to 12 months
waist circumstance (cm)
diastolic blood pressure change
Time Frame: change from baseline up to 12 months
diastolic blood pressure/mmHg
serum total cholesterol (TC) change
Time Frame: change from baseline up to 12 months
serum total cholesterol (TC) (mmol/L)
Body mass index change
Time Frame: change from baseline up to 12 months
Body mass index(BMI) weight/height square (kg/㎡)
Secondary Outcomes
- activities of daily living score change(change from baseline up to 12 months)
- pain score change(change from baseline up to 12 months)
- knee related quality of life score change(change from baseline up to 12 months)
- symptoms score change(change from baseline up to 12 months)
- function in sport and recreation score change(change from baseline up to 12 months)