Demineralized Whole-tooth vs Demineralized Particulate Dentin Grafts in Alveolar Ridge Preservation
- Conditions
- Alveolar Bone Loss
- Interventions
- Procedure: Alveolar ridge preservation using whole-tooth dentin graftProcedure: Alveolar ridge preservation using particulate dentin graft
- Registration Number
- NCT05336149
- Lead Sponsor
- Cairo University
- Brief Summary
The aim of this trial is to compare whole-tooth vs particulate dentin for their effects in alveolar ridge preservation.
- Detailed Description
Extraction of the teeth is still one of the most commonly undertaken procedures in dental practices due to various reasons that render the teeth non-restorable. Following extraction, replacing the lost teeth with a prosthetic alternative that provides for both optimal esthetics and function can be challenging due to the inevitable events of socket healing that results in the reduction in alveolar bone height and width. To overcome these limitations and provide for adequate ridge volume, different bone preservation or augmentation techniques can be utilized with different clinical applications.
Alveolar ridge preservation is a procedure that attempts to reduce bone dimensional changes that naturally take place following tooth extraction. To overcome this problem, various approaches using various grafting materials and/or covering membranes have been proposed with varied success. The extracted tooth is no longer considered as clinical waste, it has been explored as an appropriate source for autogenous graft substitute. This idea emerged due to the shared embryonic origin of bone and teeth as well as the similarities in chemical structure as dentin is composed of 30-35% organic part and 65-70% inorganic part in comparison to alveolar bone, with inorganic and organic parts of 35% and 65% respectively. Both whole-tooth and particulate forms has been utilized for alveolar ridge preservation or augmentation but the superiority of one form over the other is not yet clear.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- Non-restorable tooth indicated for extraction
- single-rooted teeth
- Patients at least 18 years or older
- Motivated patients, agree to sign informed consent and complete the follow-up period
- Pregnant females
- active infection at extraction site
- Smokers
- systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Whole-tooth dentin graft Alveolar ridge preservation using whole-tooth dentin graft The extracted tooth will be prepared as whole-tooth dentin graft and inserted in the extraction socket. Particulate dentin graft Alveolar ridge preservation using particulate dentin graft The extracted tooth will be prepared as particulate dentin graft and inserted in the extraction socket.
- Primary Outcome Measures
Name Time Method Alveolar bone width change in mm 6 months Alveolar bone linear width will be measured at baseline at final cone beam computed tomography (CBCT) scans. The change in bone width will be calculated as the subtraction of final width from baseline width and will be expressed in millimetres.
- Secondary Outcome Measures
Name Time Method Alveolar bone height change in mm 6 months Alveolar bone linear height will be measured at baseline at final cone beam computed tomography (CBCT) scans. The change in bone height will be calculated as the subtraction of final height from baseline height and will be expressed in millimetres.
Histological assessment 6 months Bone samples from at least one control and one intervention site will be taken during implant placement using a trephine bur. Samples will be examined for new bone formation (Yes/no) and inflammatory response (Yes/no).
Trial Locations
- Locations (1)
Cairo University
🇪🇬Cairo, Egypt