跳至主要内容
临床试验/NCT05336149
NCT05336149Unknown不适用

Demineralized Whole-tooth vs Demineralized Particulate Dentin Grafts in Alveolar Ridge Preservation. a Randomized Controlled Trial.

Cairo University1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2022年6月最近更新:
适应症

试验速览

阶段
不适用
入组人数
20
试验地点
1
主要终点
Alveolar bone width change in mm

研究概览

简要总结

The aim of this trial is to compare whole-tooth vs particulate dentin for their effects in alveolar ridge preservation.

详细描述

Extraction of the teeth is still one of the most commonly undertaken procedures in dental practices due to various reasons that render the teeth non-restorable. Following extraction, replacing the lost teeth with a prosthetic alternative that provides for both optimal esthetics and function can be challenging due to the inevitable events of socket healing that results in the reduction in alveolar bone height and width. To overcome these limitations and provide for adequate ridge volume, different bone preservation or augmentation techniques can be utilized with different clinical applications.

Alveolar ridge preservation is a procedure that attempts to reduce bone dimensional changes that naturally take place following tooth extraction. To overcome this problem, various approaches using various grafting materials and/or covering membranes have been proposed with varied success. The extracted tooth is no longer considered as clinical waste, it has been explored as an appropriate source for autogenous graft substitute. This idea emerged due to the shared embryonic origin of bone and teeth as well as the similarities in chemical structure as dentin is composed of 30-35% organic part and 65-70% inorganic part in comparison to alveolar bone, with inorganic and organic parts of 35% and 65% respectively. Both whole-tooth and particulate forms has been utilized for alveolar ridge preservation or augmentation but the superiority of one form over the other is not yet clear.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Non-restorable tooth indicated for extraction
  • single-rooted teeth
  • Patients at least 18 years or older
  • Motivated patients, agree to sign informed consent and complete the follow-up period

排除标准

  • Pregnant females
  • active infection at extraction site
  • systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...)

结局指标

主要结局

Alveolar bone width change in mm

时间窗: 6 months

Alveolar bone linear width will be measured at baseline at final cone beam computed tomography (CBCT) scans. The change in bone width will be calculated as the subtraction of final width from baseline width and will be expressed in millimetres.

次要结局

  • Alveolar bone height change in mm(6 months)
  • Histological assessment(6 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Mohamed AbdelRaouf Hussein

Principal investigator

Cairo University

研究点 (1)

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