Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
- Conditions
- TraumaInflammation
- Registration Number
- NCT03622632
- Lead Sponsor
- Hopital du Sacre-Coeur de Montreal
- Brief Summary
The goal of this project, is to better understand the fluctuation of the level of uric acid in traumatized patients by making serial measurements during their hospitalization in the intensive care unit. In addition, the determinants (e.g. type of trauma, diseases, interventions) of the blood level of uric acid and its association with the development of organ failure will be sought.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 25
- Direct admission to trauma center
- ≤ 3h after trauma
- ISS ≥ 16
- Received at least 1L of fluid at ER entrance
- Isolated head injury
- Isolated spine injury
- Chemotherapy within the last month
- Hematologic disease
- Chronic hemodialysis
- Uricase treatment within the last week
- Expected death within 48h
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Feasibility of serial plasmatic uric acid sampling after trauma 7 days Number of measures collected/number of measures planned
- Secondary Outcome Measures
Name Time Method Clinical predictors of the first blood uric acid (μmol/L) level measured 12 hours Impact of patient's characteristics and physiological variables on the first measured blood uric acid.
Characteristics will include: age (years), gender, Injury severity score, presence of acute renal impairment.
Physiological variables will include: lower systolic blood pressure, base deficit, lactate levelImpact of resuscitation on uric acid measures 24 to 48 hours Impact of fluid administration (amount in mL) on the changes of subsequent uric acid blood level
Trial Locations
- Locations (1)
Hôpital du Sacré-Cœur de Montréal
🇨🇦Montreal, Quebec, Canada