Platelet inhibition with cangrelor in unconcious survivors of out-of-hospital cardiac arrest undergoing cardiac artery stent implantatio

Phase 1

• Conditions: Comatose survivors of out-of-hospital cardiac arrest undergoing primary percutaneous coronary intervention; Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]

• Registration Number: EUCTR2019-001285-15-SI
• Lead Sponsor: niversity Medical Centre Ljubljana

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-25
• Last Update Posted: 21 May 2024

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

- age 18 to 70 years
- comatose survivors of out-of-hospital cardiac arrest undergoing primary percutaneous coronary intervention
- treatment with induced therapeutic hypothermia
- no contraindication for dual antiplatelet therapy

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 30
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 30

Exclusion Criteria

- pregnancy
- patients without return of spontaneous circulation or patients on ECMO
- history of recent P2Y12 use (last 7 days)
- history of recent vitamin K antagonist or NOAC use (last 14 days)
- active bleeding
- history of transient ischemic attack or cerebral vascular insult
- strong bleeding tendency (Child C liver cirrhosis, stage IV-V chronic renal disease)
- history of allergic reactions to acetylsalicylic acid, heparin or P2Y12 inhibitors
- terminal disease or life expectancy less than 1 year

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified