To compare the effect of bous intravenous dose of Dexmedetomidine versus Magnesium Sulphate on induction dose of Propofol in patients undergoing general anaesthesia

Not yet recruiting

• Conditions: Hernia, (2) ICD-10 Condition: K35-K38||Diseases of appendix, (3) ICD-10 Condition: K20-K31||Diseases of esophagus, stomach and duodenum, (4) ICD-10 Condition: K00-K14||Diseases of oral cavity and salivary glands, (5) ICD-10 Condition: K80-K87||Disorders of gallbladder, biliary tract and pancreas, (6) ICD-10 Condition: H60-H95||Diseases of the ear and mastoid process, (7) ICD-10 Condition: N60-N65||Disorders of breast,

• Registration Number: CTRI/2023/08/056866
• Lead Sponsor: DR ANAND S

Brief Summary

Propofol is a universally used induction agent. Despite it’s favourable profile, higher doses may be required which can cause adverse cardiorespiratory effects. Alpha-2 adrenoceptor agonists, such as dexmedetomidine, are known to possess amnesic, analgesic, sympatholytic, and antinociceptive properties, and therefore, can reduce the requirement of anesthetics and opioids intraoperatively. Administration of MgSO4 has also shown significant reduction in the perioperative requirement of propofol, opioids, and muscle relaxants.Our goal is to titrate the dose of propofol during induction till there is a loss of verbal response by giving a bolus of dexmedetomidine or magnesium sulphate or normal saline (control group) and to compare the intubation response in all three groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-09
• Last Update Posted: 2023-08-17

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• ASA Grade I and Grade II patients b.
• Age 18 yrs –60yrs.
• Elective surgeries.

Exclusion Criteria

• Refusal of consent b.
• Known or anticipated difficult airway.
• Emergency surgeries.
• Pregnant patients.
• Patients with heart block f.
• Patients on Beta blockers g.
• Bradycardia h.
• BMI >30kg/m2.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
For comparing the dose of Propofol needed during induction of anaesthesia after giving a bolus dose of Dexmedetomidine or Magnesium Sulphate or Normal saline in general anaesthesia	Baseline,After Drug bolus,After propofol induction

Secondary Outcome Measures

Name	Time	Method
a) To check the intubation response between the three groups-heart rate,blood pressure,saturation.	b) Time required for TOF value to change from 0 to 1

Trial Locations

Locations (1)

CHETTINAD ACADEMY OF RESEARCH AND EDUCATION; 🇮🇳 Kancheepuram, TAMIL NADU, India

CHETTINAD ACADEMY OF RESEARCH AND EDUCATION

🇮🇳Kancheepuram, TAMIL NADU, India

DRHARSHANAA G

Principal investigator

9176258393

harshanaa.g@gmail.com