International Lung Screen Trial

The University of Queensland6 sites in 2 countries2,000 target enrollmentApril 5, 2017

ConditionsNon-small Cell Lung Cancer Lung Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Neoplasms Lung Diseases Respiratory Tract Diseases Smokers at Risk of Lung Cancer

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Non-small Cell Lung Cancer
Sponsor: The University of Queensland
Enrollment: 2000
Locations: 6
Primary Endpoint: Change in quality of life
Status: Active, not recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

People who may be at increased risk of lung cancer due to age and smoking history will be invited to participate in this international study to determine the best way of using computed tomography (CT) of the chest to screen for early lung cancer. Overseas data show that CT screening (screening tests can find diseases early, when they're easier to treat) can reduce deaths from lung cancer and this study will help determine who is most likely benefit from screening.

Detailed Description

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Registry

clinicaltrials.gov

Start Date

April 5, 2017

End Date

December 2025

Last Updated

2 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

The University of Queensland

Responsible Party

Principal Investigator

Kwun Fong

Professor

The University of Queensland

Eligibility Criteria

Inclusion Criteria

•Women or men age from 55 to
•Current or former smokers. A former smoker is defined as one who has stopped smoking for one or more years.
•An estimated 6-year lung cancer risk of ≥1.51% based on the PLCOm2012 risk prediction model or ≥ 30 pack-years smoking history (pack-year is defined as number of pack of cigarettes smoked per day multiply by the number of years smoked. If a participant stopped smoking for 6 months or more and then restarted smoking again, the time will be subtracted from the total duration of smoking in 0.5 year increments)
•ECOG performance status 0 or
•Capable of providing, informed consent for screening procedures (low dose spiral CT)
•Exclusion Criteria
•Clinical symptoms suspicious for lung cancer e.g. hemoptysis, chest pain, weight loss
•Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, home oxygen therapy, bleeding disorder, that in the opinion of the investigator could jeopardize the subject's safety during participation in the study or unlikely to benefit from screening due to shortened life-expectancy from the co-morbidities
•Have been previously diagnosed with lung cancer
•Have had other non-curatively treated cancer outside the lung.