A clinical trial to study the effect of addition of dexmedetomidine with local anesthesia on pain relief after arm and hand surgery

Not Applicable

Completed

• Conditions: scheduled for forearm and hand surgeries

• Registration Number: CTRI/2013/12/004209
• Lead Sponsor: Director

Brief Summary

This prospective randomized double blind study was conducted to assess the effects of dexmedetomidine as an adjunct to local anesthetics in supraclavicular brachial plexus block on postoperative analgesia and block characteristics. Sixty adult patients of ASA grade 1 and 2 undergoing upper limb surgery were randomly allocated into two groups. Control group received equal volume of 0.75% ropivacaine and 2% lidocaine with adrenaline (1 in 2,00000) while dexmedetomidine group received I mcg/kg dexmedetomidine along with similar local anesthetics (total volume being 0.5 ml/kg in both groups) in supraclavicular brachial plexus block.Patients were observed for hemodynamic stability, onset and duration of block, postoperative pain, duration of analgesia, sedation and any adverse effects. We observed that addition of dexmedetomidine to local anesthetics in supraclavicular brachial plexus block significantly increases the duration of postoperative analgesia and reduces the requirement of rescue analgesia. The onset of block was faster and the duration was prolonged in dexmedetomidine group as compared to control group. Patients in dexmedetomidine group were sedated but easily arousable. No adverse effects like hypotension, bradycardia, hypoxia or respiratory depression were reported.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-08-11
• Last Update Posted: 2014-03-27

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

60 patients of either sex aged between 20-60 years, ASA physical status I-II, scheduled for forearm and hand surgeries were included.

Exclusion Criteria

Patients receiving adrenoreceptor agonist or antagonist, neurological deficit in the upper limb, history of cardiac disease, respiratory disease, renal and hepatic failure, pregnant women and allergy to local anesthetics were excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative pain and Duration of analgesia(time interval from administration of block to 1st rescue analgesia required)	Postoperative pain was assessed every 30 min for 2 hr, every 1 hr for 6 hr, every 2 hr till 12 hr, | and then at 24 hr postoperatively

Secondary Outcome Measures

Name	Time	Method
onset and duration of sensory and motor blockade	assessed every 5 min till 30 min and then every 30 min till resolution of block

Trial Locations

Locations (1)

Operation Theater Nehru Hospital; 🇮🇳 Chandigarh, CHANDIGARH, India

Operation Theater Nehru Hospital

🇮🇳Chandigarh, CHANDIGARH, India

Neerja Bharti

Principal investigator

9915575145

bhartineerja@yahoo.com