Impact of markers like D-Dimer and Coagulation parameters in predicting outcome in COVID-19 patients

Not yet recruiting

Conditions: Coronavirus as the cause of diseases classified elsewhere,

Registration Number: CTRI/2021/04/033047

Lead Sponsor: Kowshik V

Brief Summary: The study is prospective and will take place in the Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Porur ,Chennai between March 2021 and March 2023 after obtaining ethical clearance. It aims to evaluate the prognostic role of D-Dimer with illness severity. We also aim to observe the coagulation parameters (PT, PTT and INR) in patients with elevated D-Dimer and assess its correlation with complications and outcome. The identification of effective laboratory biomarkers capable of triaging patients with COVID-19 infection is very necessary taking into account the unpredictable course of the disease. Studies have shown a significant relation between D-Dimer levels and disease progression. Using the pre-structured proforma, patient’s clinical and laboratory data are collected and analysed after getting their consent. D-dimer values, course in hospital - oxygen requirement , drugs used with dosage, complications or adverse events that have occurred will all be recorded and statistical analysis will be done to correlate the two. The results of our study will help prompt triaging of the high risk patients and help rethink our treatment approach.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 400

Inclusion Criteria

RT-PCR of nasopharyngeal or oropharyngeal swab confirmed COVID-19 patients more than or equal to 18 years of age and either gender hospitalized for the illness.

Exclusion Criteria

COVID-19 positive patients less than 18 years of age Patients on pre-hospitalization anti-coagulation Patients with cancer and prior thrombocytopenia or coagulopathy Patients having hospital stay less than 3 days.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical recovery of the patient	At baseline at 4 weeks

Secondary Outcome Measures

Name	Time	Method
Complications during the hospital stay and immediately after discharge	At baseline at 4 weeks

Trial Locations

Locations (1): Sri Ramachandra Institute of Higher Education and Research
🇮🇳
Chennai, TAMIL NADU, India
Sri Ramachandra Institute of Higher Education and Research
🇮🇳Chennai, TAMIL NADU, India
Kowshik V
Principal investigator
8220281380
vkowshik94@gmail.com