Study of the Difference Between Anorexia Nervosa with a History of Psychological Trauma and Classical Anorexia Nervosa on the Neurocognitive and Neurophysiological Factors
- Conditions
- Anorexia Nervosa
- Interventions
- Behavioral: Exposition Test
- Registration Number
- NCT04804358
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
Recent studies suggest that patients with an history of trauma may represent a specific subtype of anorexia nervosa (AM) underlined by specific neurobiological and psychopathological mechanisms. Thus, AM-T subjects would manifest cognitive (specific difficulties in executive functions), emotional (emotional disruption, impulsivity, etc.) and neurobiological (secretion of kynurenine and neurokinins in the face of stress) caracteristics different from those of AM subjects.
- Detailed Description
We will recruit a total of 100 patients with a diagnosis of anorexia nervosa in the university hospital of Montpellier : 50 patients with an history of psychological trauma and 50 patients without any history of psychological trauma
Participation consists of a half-day visit. Patients will perform clinical and neuropsychological assessments and an exposition test. During this test, participants will be exposed, for 7 minutes, to neutral, positive or negative emotional photos. Heart rate variability will be determined through a Biopac MP160 before, during and after this event. Saliva samples to measure kynurenin, tryptophan, substance P and neurokinin-1 will be collected before and directly after the test.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- 4
Not provided
- Present a severe unstable mental pathology in the opinion of the investigator
- Present active suicidal ideation
- Have consumed psychoactive substances in the last 24 hours before the assessment
- Present a severe major depressive episode incompatible with the assessment, in the opinion of the investigator.
- Present in the opinion of the investigator an unstable somatic state (eg severe metabolic disorder making it impossible or likely to impair the reliability of neuropsychological and cardiac evaluations).
- Take a drug treatment acting on the cardiovascular system
- Refusal of the patient
- Be protected by law (tutorship or curatorship).
- To be deprived of liberty by administrative decision.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Anorexic women Exposition Test Anorexic women with or without history of psychological trauma will perform study procedure : sociodemographic and clinical assessments, measurement of cardiac variability and salivary cortisol changes, before, during and after the exposition test.
- Primary Outcome Measures
Name Time Method Changes in high frequency heart variability (HF-HRV) across the exposition test (before, during and after) inclusion visit We aim to investigate if AM-T patients present changes in HF-HRV across exposition test compared to AM-C patients, measured by Biopac MP160
- Secondary Outcome Measures
Name Time Method Changes in very low frequency heart variability (VLF-HRV) across the exposition test (before, during and after) inclusion visit We aim to investigate if AM-T patients present changes in VLF-HRV across exposition test compared to AM-C patients, measured by Biopac MP160
Changes in low frequency heart variability (LF-HRV) across the exposition test (before, during and after) inclusion visit We aim to investigate if AM-T patients present changes in LF-HRV across exposition test compared to AM-C patients, measured by Biopac MP160
Score to the Beck depression inventory II inclusion visit We aim to assess the link between eating symptomatology and psychological trauma in AN. The BDI-II is a self-administered questionnaire assessing the severity of depressive symptoms in 21 items. Each item is rated on a 4-points Likert scale ranging from 0 to 3. The total score varies between 0 and 63. higher scores mean more depressive symptoms
Score to the Eating Disorder Questionnaire inclusion visit We aim to assess the link betxeen eating symptomatology and psychological trauma in AN. self-administered questionnaire assessing the intensity of eating symptoms over the past 28 days. A total score as well as 4 sub-scores (restriction, diet, weight, shape) varying from 0 to 6 are obtained.Higher scores mean higher eating concerns
Changes in the interval between R peaks (R-R across the exposition test (before, during and after) inclusion visit We aim to investigate if AM-T patients present R-R changes across exposition test compared to AM-C patients, measured by Biopac MP160
Changes in the root mean successive squared differences of the R-R interval (RMSSD). across the exposition test (before, during and after) inclusion visit We aim to investigate if AM-T patients present RMSSD changes across exposition test compared to AM-C patients, measured by Biopac MP160
Score to the Difficulties in Emotion Regulation Scale inclusion visit We aim to assess the link between emotional regulation and psychological trauma in AN. DERS is a self-assessment scale measuring emotion dysregulation. The original DERS includes 36 items scored 1-5 where 1 is almost never, 2 is sometimes, 3 is about half the time, 4 is most of the time, and 5 is almost always. Of the 36 items, 11 are reverse scored. The DERS-36 yields a total score as well as six subscales where higher scores indicate more difficulties.
Score to the Delay Discounting Test inclusion visit We aim to assess the link between decision making and psychological trauma in AN
Changes in the highest peak of the high frequency (HFhz) across the exposition test (before, during and after) inclusion visit We aim to investigate if AM-T patients present changes in HFhz across exposition test compared to AM-C patients, measured by Biopac MP160
Score to the Eating Disorder Inventory inclusion visit We aim to assess the link between eating symptomatology and psychological trauma in AN. The EDI-2 is a 91-item self-report questionnaire assessing cognitive, emotional, and behavioral symptoms of eating disorders. It rates from 0 to 273. Higher scores means severe symptoms
Score to the Childhood trauma questionnaire inclusion visit Score to the Trail Making Test inclusion visit We aim to assess the link between mental flexibility, visio-spatial attention, processing speed and psychological trauma in AN
Changes in salivary tryptophan inclusion visit study changes in salivary tryptophan before and after exposition test
Changes in the R-R interval standard difference (STD-RR) across the exposition test (before, during and after) inclusion visit We aim to investigate if AM-T patients present STD-RR changes across exposition test compared to AM-C patients, measured by Biopac MP160
Score to the PTSD Checklist for DSM-5 inclusion visit Changes in salivary kynurenine inclusion visit study changes in salivary kynurenine before and after exposition test
Changes in salivary neurokinin-1 inclusion visit study changes in salivary neurokinin-1before and after exposition test
Score to the Wisconson Card Sorting Test inclusion visit We aim to assess the link between mental flexibility, working memory, inhibition and psychological trauma in AN
Score to the Stroop Test inclusion visit We aim to assess the link between mental flexibility, working memory, inhibition and psychological trauma in AN
Changes in salivary P substance inclusion visit study changes in salivary P substance before and after exposition test
Trial Locations
- Locations (1)
University Hospital, Montpellier
🇫🇷Montpellier, France