3D printed POLYLACTIC-CO-GLYCOLIC ACID(PLGA)scaffolds for bone regeneration in osseous defects of maxilla and mandible.
Overview
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- ANIL NERUKONDA INSTITUTE OF DENTAL SCINCES
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Efficacy of PLGA SCAFFOLDS
Overview
Brief Summary
Craniomaxillofacial surgeries often involve complex bone reconstructions due to trauma, congenital anomalies, or tumor resections. Current approaches have limitations in terms of graft availability, donor site morbidity, and suboptimal outcomes. PLGA is a biocompatible and biodegradable polymer widely used in medical applications. Utilizing PLGA scaffolds for bone regeneration could offer a minimally invasive and effective alternative in maxilla and mandible.
Objective: This proposal aims to investigate the efficacy and safety of Poly (lactic-co-glycolic acid) (PLGA) scaffolds as a regenerative solution for bone defects in craniomaxillofacial surgeries. The project will assess the ability of PLGA scaffolds to promote bone regeneration, accelerate healing, and improve patient outcomes, while adhering to the highest ethical standards.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 45.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients with Cystic Defects of the Maxilla and Mandible after cyst enucleation Primary defects after cyst enucleation less than 4cm.
Exclusion Criteria
- •Patients with sytemic disease patients on calcium and vitamin d supplementation.
Outcomes
Primary Outcomes
Efficacy of PLGA SCAFFOLDS
Time Frame: assessment of bone formed at 4th week and 12th week with CT evaluation
Secondary Outcomes
- assessment of bone density formed at 4th week and 12th by histomorphic analysis(4th week,12th week.)
Investigators
Dr.Venkata ramana murthy v
anil neerukonda isntitute of dental sciences