3D printed POLYLACTIC-CO-GLYCOLIC ACID(PLGA)scaffolds for bone regeneration in osseous defects of maxilla and mandible.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Efficacy of PLGA SCAFFOLDS
研究概览
简要总结
Craniomaxillofacial surgeries often involve complex bone reconstructions due to trauma, congenital anomalies, or tumor resections. Current approaches have limitations in terms of graft availability, donor site morbidity, and suboptimal outcomes. PLGA is a biocompatible and biodegradable polymer widely used in medical applications. Utilizing PLGA scaffolds for bone regeneration could offer a minimally invasive and effective alternative in maxilla and mandible.
Objective: This proposal aims to investigate the efficacy and safety of Poly (lactic-co-glycolic acid) (PLGA) scaffolds as a regenerative solution for bone defects in craniomaxillofacial surgeries. The project will assess the ability of PLGA scaffolds to promote bone regeneration, accelerate healing, and improve patient outcomes, while adhering to the highest ethical standards.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with Cystic Defects of the Maxilla and Mandible after cyst enucleation Primary defects after cyst enucleation less than 4cm.
排除标准
- •Patients with sytemic disease patients on calcium and vitamin d supplementation.
结局指标
主要结局
Efficacy of PLGA SCAFFOLDS
时间窗: assessment of bone formed at 4th week and 12th week with CT evaluation
次要结局
- assessment of bone density formed at 4th week and 12th by histomorphic analysis(4th week,12th week.)
研究者
Dr.Venkata ramana murthy v
anil neerukonda isntitute of dental sciences