Effect of Intradialytic Exercise Intervention on Dialysis Adequacy in Patients with End Stage Kidney Disease Undergoing Hemodialysis at Dr. Sardjito: Single Center Study (Study of Body Composition, Nutritional Status, Cardiovascular Response, Quality of Life, Sleep Quality, and Depression Status)

Phase 2

Completed

• Conditions: chronic kidney diseaseend-stage kidney diseasehemodialysisdialysis adequacyquality of lifebody compositionnutritional statusinflammatory marker; Intradialytic aerobic exercise; chronic kidney disease; end-stage kidney disease; hemodialysis; dialysis adequacy

• Registration Number: TCTR20240327002
• Lead Sponsor: Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada

Brief Summary

There was a significant increase in Kt/V and URR (%) in the intervention group compared to the control group. In addition, quality of life also improved significantly with KDQOL-36 summary score was significantly higher in the intervention group. Multivariate analysis showed that intradialysis exercise, female gender, and intradialysis diastolic pressure can significantly affect Kt/V changes.

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-07-22
• Study Start: 2024-03-27
• Results First Posted: 2024-06-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

The inclusion criteria for this study are patients aged >18 years, receiving routine conventional HD therapy for >3 months, stable condition with no history of worsening conditions (extra HD) in the last month, and using AV fistula/graft vascular access.

Exclusion Criteria

The exclusion criteria for this study are patients with acute clinical infection or sepsis, pregnant or lactating patients, patients undergoing hemodialysis for acute dialysis indications in the last month, malignancy or autoimmune disease, neurological disorders, especially in the lower extremities, and patients with musculoskeletal system disorder that restrict them from participating in intradialytic exercise

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dialysis adequacy 12 weeks Kt/V, URR calculation, blood examination (potassium, calcium, phosphat, hemoglobin), blood pressure examination

Secondary Outcome Measures

Name	Time	Method
Quality of Life 12 weeks KDIQoL-36 score,Body composition 12 weeks BioImpedance Analysis (BIA),Nutritional Status 12 weeks MIS score, urea/creatinine ratio, and iron profile,Inflammatory marker 12 weeks Blood examination