NCT00526019已完成不适用
Characteristics of Symptomatic Asthma Remissions
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
研究概览
简要总结
This study aims at determining the patterns of asthma remission, the prevalence of these different patterns, the various factors associated with such remissions and possible recurrences of asthma, in order to determine the mechanisms involved in these processes.
The investigators therefore want to document these specificities in subjects in complete remission of their asthma, and those in only symptomatic remission of their asthma, in comparison with mildly symptomatic asthmatic subjects and healthy controls.
详细描述
Primary Outcome Measures :
- Airway inflammation (% induced sputum eosinophils)
Secondary Outcome Measures:
- Perception of induced respiratory symptoms
- Airway response to methacholine and AMP, and perception scores
- Diurnal variation in Peak Expiratory Flows
- Profile of regulatory T cells in the peripheral blood
- Changes in these parameters over time (baseline, 6 months, 1 and 2 years)
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •In remission of their asthma: absence of respiratory symptoms, no rescue asthma medication need and (for complete remission) an optimal pulmonary function (FEV1 > 90%) and normal PC20 methacholine for more than two years (with no current treatment).
- •With a proven past history of asthma from medical files (reversible airway obstruction (> 12% FEV1 after bronchodilator or 20% by other means) proven by spirometry, PEF measures or methacholine challenge according to current criteria + previous symptoms and asthma medication use), having no more asthma symptoms and not having used asthma medication for more than 2 years.
- •Agree to sign the consent form.
- •No other condition that could interfere with the study measurements.
排除标准
- •Unable to adhere to the protocol requirements.
- •Other current respiratory disease.
- •Upper or lower respiratory tract infection or use of antibiotics < 1 month.
- •Use of oral corticosteroids within the last 3 months.
- •Signs or symptoms of progressive or uncontrolled renal, hepatic, hematologic, endocrine, pulmonary, cardiac, neurologic, or cerebral disease.
研究者
Louis-Philippe Boulet
MD, FRCPC, FCCP
Laval University
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