Efficacy of compression stockings for treating recurrent vasovagal syncope: a triple-blind, multi-center, randomized controlled trial (COMFORTS-II)

Tehran University of Medical Sciences0 个研究点目标入组 268 人开始时间: 待定最近更新: 2022年11月21日

适应症

试验速览

暂无简介。

•Patients with 18 = age = 65 years
•Vasovagal syncope as the cause of transient loss of conscious confirmed by Clinical diagnosis AndCalgary syncope system score (CSSS) =-2
•=2 episodes of VVS during the last year
•Capability of giving informed consent

•Orthostatic hypotension (decrease in BP =20/10 mmHg after 5-minute stand test)
•Postural tachycardia (increase in heart rate =30 bpm after 5-minute stand test)
•Carotid sinus hypersensitivity (ventricular pause >3 or decrease in BP > 50 mmHG after carotid sinus massage, performed in patients 40 years or older)
•History of Seizure
•Currently using medications for treatment of vasovagal syncope
•Cardiac rhythm disorders including ventricular tachycardia, long QT syndrome, Brugada syndrome, arrhythmogenic right ventricular cardiomyopathy, complete heart block, or any conduction abnormality on ECG
•Severe valvular heart disease
•Hypertrophic cardiomyopathy
•Cardiac systolic dysfunction (ejection fraction =40%)
•Obstructive coronary artery disease
•Cardiac implantable electronic devices
•Prior recommendation of compression stocking by a health-care provider, or other indication for compression stocking use
•Foot ulcers and diabetic foot
•Chronic venous insufficiency
•Renal failure stage =3 (eGFR <60 mL/min/1.73 m2)
•Presence of a chronic severe illness
•Pregnancy, or intention to become pregnant in the next year
•Unwillingness to participate or to provide informed consent

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