Evaluation of Photobiomodulation in topical anesthetic absorption and pain reduction during Local Infiltrative Anesthesia

Phase 2

• Conditions: Pulpitis; Root Caries; C07.793.720.210

• Registration Number: RBR-9sfj4rz
• Lead Sponsor: Pontifícia Universidade Católica de Campinas

Brief Summary

This work aims to evaluate the applicability of the photobiomodulation (PMB) to help in the absorption of the topical anaesthetic, and in the reduction of the pain during the local infiltrating anesthesia in the dental clinic. A split-mouth study was made in 20 patients who needed previous infiltrating anesthesia. The teeth that required infiltrating anesthesia, from the same patient, were randomly divided into 2 groups (n =20): Sham (S), and Photobiomodulation (PMB). In the PMB group, was performed the local and systemic photobiomodulation. The systemic photobiomodulation was performed with a low-intensity laser, with power of 60 J in continuous mode, for 10 minutes, in the radial artery, power of 100 mW in wavelength 660 nm (red light). The local photobiomodulation was made with 6 J for one minute, in the oral mucosa region, power of 100 mW, and wavelength of 780 nm (infrared light). After the PMB, the topical anesthetic 20% benzocaine was administered. In the Sham group, it was used the simulation of the laser on the patient's radial artery and oral mucosa prior to the application of the topical anesthetic 20% benzocaine. In both groups, the perception of pain was measured using the Visual Analogue Scale (VAS). The results were submitted to the t test. There was a significant reduction in pain during the infiltrating anesthesia in the teeth that received photobiomodulation before the application of the topical anesthetic compared to the teeth that were anesthetized without the laser application (p<0.0001). It can be concluded that the use of the photobiomodulation before the application of the topical anesthetic can be a clinical option in pain control during infiltrating anesthesia.

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-04-26
• Study Start: 2024-07-09
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients who require at least 2 infiltrative anesthesias to carry out their dental treatment plan. Anterior teeth or premolars. Patients without systemic impairment. Patients aged between 18 and 50 years. Both genders

Exclusion Criteria

Patients who are undergoing antidepressant or antipsychotic drug treatments. Pregnant women

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Outcome found 1: There was a reduction in pain during needle puncture for local anesthesia in the group where topical anesthetic and low-intensity laser were Applied;Expected outcome 1: It is expected that there will be a reduction in pain during needle puncture for injection of local anesthesia in the group where the topical anesthetic was applied combined with the application of low-intensity laser

Secondary Outcome Measures

Name	Time	Method
o secondary outcomes were expected.