LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population
- Conditions
- Age-Related Macular Degeneration
- Interventions
- Genetic: LOC387715/HTRA1 genotyping
- Registration Number
- NCT01108250
- Lead Sponsor
- Kyungpook National University Hospital
- Brief Summary
This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy and whether they are associated with clinical patterns including angiographic phenotype in a Korean population.
- Detailed Description
This is a cross-sectional case-control study. One hundred Korean patients with polypoidal choroidal vasculopathy and 100 control subjects were genotyped for the LOC387715 (rs10490924) and the HTRA1 gene polymorphism (rs11200638)
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 215
- patients older than 60 years of age at onset
- polyp-like terminal aneurysmal dilations with or without branching vascular networks in indocyanine green angiography and subretinal reddish-orange protrusions corresponding to polyp-like lesions
- eyes with pathologic myopia, angioid streaks, central serous chorioretinopathy, and other retinal or choroidal diseases
Control group
Inclusion Criteria:
- individuals without retinal diseases and without any signs of polypoidal choroidal vasculopathy or age-related macular degeneration on the bases of comprehensive ophthalmic examination results
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description polypoidal choroidal vasculopathy LOC387715/HTRA1 genotyping patients with polypoidal choroidal vasculopathy control LOC387715/HTRA1 genotyping control group with no polypoidal choroidal vasculopathy
- Primary Outcome Measures
Name Time Method Genotyping of LOC387715/HTRA1 of PCV and control groups 4weeks to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy (PCV)
- Secondary Outcome Measures
Name Time Method Indocyanine angiographic findings of polypoidal choroidal vasculopathy 20 minutes The association of the risk allele of the LOC387715/HTRA1 and indocyanine angiographic characteristics of polypoidal choroidal vasculopathy including subretinal hemorrhage, pigment epithelial detachment, and serous retinal detachment.
Visual acuity using Snellen chart 2 x 5 minutes To evaluate the association between visual acuity and genotype of polypoidal choroidal vasculopathy
Trial Locations
- Locations (1)
In Taek Kim
🇰🇷Daegu, Kyungsangpookdo, Korea, Republic of