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LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population

Not Applicable
Completed
Conditions
Age-Related Macular Degeneration
Interventions
Genetic: LOC387715/HTRA1 genotyping
Registration Number
NCT01108250
Lead Sponsor
Kyungpook National University Hospital
Brief Summary

This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy and whether they are associated with clinical patterns including angiographic phenotype in a Korean population.

Detailed Description

This is a cross-sectional case-control study. One hundred Korean patients with polypoidal choroidal vasculopathy and 100 control subjects were genotyped for the LOC387715 (rs10490924) and the HTRA1 gene polymorphism (rs11200638)

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
215
Inclusion Criteria
  • patients older than 60 years of age at onset
  • polyp-like terminal aneurysmal dilations with or without branching vascular networks in indocyanine green angiography and subretinal reddish-orange protrusions corresponding to polyp-like lesions
Exclusion Criteria
  • eyes with pathologic myopia, angioid streaks, central serous chorioretinopathy, and other retinal or choroidal diseases

Control group

Inclusion Criteria:

  • individuals without retinal diseases and without any signs of polypoidal choroidal vasculopathy or age-related macular degeneration on the bases of comprehensive ophthalmic examination results

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
polypoidal choroidal vasculopathyLOC387715/HTRA1 genotypingpatients with polypoidal choroidal vasculopathy
controlLOC387715/HTRA1 genotypingcontrol group with no polypoidal choroidal vasculopathy
Primary Outcome Measures
NameTimeMethod
Genotyping of LOC387715/HTRA1 of PCV and control groups4weeks

to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy (PCV)

Secondary Outcome Measures
NameTimeMethod
Indocyanine angiographic findings of polypoidal choroidal vasculopathy20 minutes

The association of the risk allele of the LOC387715/HTRA1 and indocyanine angiographic characteristics of polypoidal choroidal vasculopathy including subretinal hemorrhage, pigment epithelial detachment, and serous retinal detachment.

Visual acuity using Snellen chart2 x 5 minutes

To evaluate the association between visual acuity and genotype of polypoidal choroidal vasculopathy

Trial Locations

Locations (1)

In Taek Kim

🇰🇷

Daegu, Kyungsangpookdo, Korea, Republic of

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