Alteration of respiratory drive in comatose out-of-hospital post cardiac arrest patients
Recruiting
- Conditions
- Out-of-hospital cardiac arrest adult patientspost cardiac arrest
- Registration Number
- TCTR20221010003
- Lead Sponsor
- Faculty of Medicine, Prince of Songkla University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
1. Age more than or equal 18 years
2. Out of hospital cardiac arrest
3. Sustained Return of spontaneous circulation (ROSC) - defined as 20 minutes with signs of circulation without the need for chest compressions.
4. Unconsciousness defined GCS < 8
5. Admitted in the medical intensive care unit or cardiac care unit within 24 h after ROSC
6. On ventilator with P0.1 available
Exclusion Criteria
1. On Extracorporeal Membrane Oxygenation
2. Obvious or suspected pregnancy
3. Intracranial bleeding
4. Severe chronic obstructive pulmonary disorder (COPD)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The airway occlusion pressure (P0.1) 24, 48 and 72 h after hospital admission P0.1 maneuver on ventilator
- Secondary Outcome Measures
Name Time Method Respiratory parameters 24, 48 and 72 h after hospital admission tidal volume, minute ventilation, respiratory rate ,Arterial blood gas 24, 48 and 72 h after hospital admission pH, pCO2, PO2,Neurological outcome At hospital discharge Cerebral performance catagories