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Clinical Trials/CTRI/2025/10/095806
CTRI/2025/10/095806
Not yet recruiting
Phase 3

To assess and compare the effectiveness of a multidisciplinary approach versus occlusal splints alone in reducing pain associated with temporomandibular disorders (TMDS): a randomized clinical trial

Akshaya Kumar Patra1 site in 1 country154 target enrollmentStarted: October 20, 2025Last updated:

Overview

Phase
Phase 3
Status
Not yet recruiting
Sponsor
Akshaya Kumar Patra
Enrollment
154
Locations
1
Primary Endpoint
pain intensity, mandibular range of motion

Overview

Brief Summary

This randomized clinical trial aims to compare a multidisciplinary approach combining occlusal splint therapy, physiotherapy, and mindfulness-based intervention with occlusal splints alone in reducing TMD related pain and improving function. A total of 154 patients aged between18 to 40 years diagnosed using RDC TMD criteria will be randomly assigned by block randomization to either the splint only group or the multidisciplinary group. Interventions will be conducted over four weeks, with follow-ups at baseline, 2 weeks, 1 month, and 2 months. Pain intensity, mandibular range of motion, and psychological well-being will be evaluated.

Study Design

Study Type
Interventional
Allocation
Randomized
Masking
Outcome Assessor Blinded

Eligibility Criteria

Ages
18.00 Year(s) to 40.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • Patients who experienced common symptoms of TMD (i.e. impaired range of movement, impaired TM-joint function, muscle pain, TM-joint pain, or pain on movement of the mandible).
  • Patients aged between 18 to 40 years.
  • Patients willing to receive treatment after informed consent.

Exclusion Criteria

  • Patients below the age of 18 years and above the age of 40 years.
  • Patients with complete or removable prosthesis with distal extensions on which it is not possible to fabricate a retentive splint.
  • Patients already having received medical, pharmacological or any form of treatments for TMD.
  • Individuals with recent facial or cervical trauma.
  • Patients under treatment for any major psychological disorders.
  • Symptoms related to disease in other components of the stomatognathic system e.g., toothache, neuralgia).
  • Cases with congenital abnormality, concomitant inflammatory or neoplastic conditions.
  • Patients not willing to participate after informed consent.

Outcomes

Primary Outcomes

pain intensity, mandibular range of motion

Time Frame: baseline, 2 weeks, 1 month, 2 months

Secondary Outcomes

  • psychological status(baseline, 2 months)

Investigators

Sponsor
Akshaya Kumar Patra
Sponsor Class
Other [self]
Responsible Party
Principal Investigator
Principal Investigator

Akshaya Kumar Patra

Kalinga Institute Of Dental Sciences

Study Sites (1)

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