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临床试验/NCT02240394
NCT02240394Unknown不适用

TCD Detection of Ophthalmic Artery Blood Flow Velocity Prediction Feasibility Study of Intracranial Pressure

Shanghai Jiao Tong University Affiliated Sixth People's Hospital1 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2014年3月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
400
试验地点
1
主要终点
Ophthalmic artery blood flow rate changes associated with intracranial pressure

研究概览

简要总结

Increased intracranial pressure is a cause of disease progression in patients with brain disease, a common cause of poor prognosis. Intracranial pressure monitoring is the observation of the disease, treatment, evaluation and important way to improve the prognosis. Non-invasive intracranial pressure monitoring can be used to stroke, intracranial hemorrhage, brain trauma, encephalitis and other patients. Ophthalmic artery originated from the internal carotid artery, the optic canal into the orbit, the entire process can be divided into intracranial optic tube segment and orbital segment. investigators' preliminary experiments show that when intracranial pressure, intracranial ophthalmic artery segment velocity increases with increasing velocity difference orbital segment. Accordingly, the investigators speculate, may be judged by the level of intracranial pressure intracranial and orbital velocity difference between the ophthalmic artery segment, and accordingly calculate the specific values of intracranial pressure. The investigators will collect brain trauma surgery, performed invasive intracranial pressure monitoring cases, the use of transcranial Doppler ultrasound velocity and different segments of the ophthalmic artery pulsatility index, the invasive intracranial pressure and comparing the measured values to calculate the the critical value of the ophthalmic artery segment intraorbital and intracranial velocity difference when intracranial pressure, thus fitting Based on projections of mathematical formulas intracranial pressure. This study will provide a non-invasive intracranial pressure monitor new approach.

详细描述

2014/08/28

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • age 18-75 years of age (including 18 and 75 years), gender, ethnic limitation;
  • have been carried out invasive intracranial pressure monitoring;
  • the patient or his agent informed consent. -

排除标准

  • the patient does not fit, measured by TCD can not be completed;
  • TCD failed to detect the satisfaction of the ophthalmic artery flow signals were;
  • patients with ocular trauma or a history of intraocular pressure -

结局指标

主要结局

Ophthalmic artery blood flow rate changes associated with intracranial pressure

时间窗: "up to 6 months"

次要结局

  • the change of the Ophthalmic artery peak sistolic velocity associated with intracranial pressure("up to 6 months")

研究者

发起方
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Xueming Wang

Chief Physician

Shanghai Jiao Tong University Affiliated Sixth People's Hospital

研究点 (1)

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