Early detection of exacerbations in mucociliary clearance diseases.
- Conditions
- Cystic FibrosisPrimary Ciliary Dyskinesia
- Registration Number
- NL-OMON26275
- Lead Sponsor
- Dept. Respiratory Medicine Academic Medical Centre, University of Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1. CF diagnosis is based on: clinical symptoms in combination with an abnormal sweat test (chloride > 60 mmol/l) and/or identification of mutations in both alleles of the CFTR gene;
2. PCD diagnosis is based on: A combination of clinical symptoms, abnormal movement of cilia on microscopic evaluation of respiratory epithelial biopsies and epithelial cell cultures, or identification of an ultra structural defect in the cilia by electron microscopy;
Exclusion Criteria
1. Mental retardation;
2. Diabetes Mellitus (CF complication);
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Relative changes in electronic nose sensors;<br /><br>2. Retention time;<br /><br>3. Abundance and mass to charge ratio from GC-MS analysis.
- Secondary Outcome Measures
Name Time Method (Change in) bacterial and viral diversity.