Pursed Lip Breathing in Interstitial Lung Disease
- Conditions
- Interstitial Lung Disease
- Interventions
- Behavioral: Pursed lip breathing
- Registration Number
- NCT02934750
- Lead Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
- Brief Summary
This randomized, cross-over study aims at describing the effect of pursed lip breathing on exercise-induced dyspnea and exercise capacity in patients with interstitial lung disease.
- Detailed Description
The use of pursed lip breathing (PLB) to improve exercise tolerance in COPD patients has been widely documented. However, its efficacy in patients with interstitial lung disease (ILD) has yet to be confirmed. This study aims to determine if PLB improves perceived exertion and exercise capacity during a six-minute walk test (6MWT) in patients with ILD. To achieve this, a prospective randomized crossover trial will be performed, in which patients with ILD and restrictive ventilatory defect will be recruited via the ILD clinic of Hôpital Notre-Dame. The study will be performed in a single visit, on the day where patients attend a routine physician-prescribed follow-up 6MWT. Patients will be asked to perform a total of two 6MWT. Patients will be randomized to perform the first test with or without using PLB, and the order will be reversed for the second test, with patients serving as their own control. During tests, ventilatory variables will be continuously measured using a portable metabolic cart. The observed parameters will be: perceived exertion using the Modified-Borg Scale, respiratory rate, minute-ventilation, heart rate, peripheral oxygen saturation, and 6-minute walk distance (6MWD). It is expected that the use of PLB will be associated with a decrease of at least one unit on the Modified Borg Scale, which would be clinically significant. Moreover, it is expected that the decrease in dyspnea with PLB will be related to a decrease in respiratory rate minute ventilation during 6MWT. The clinical impact of this study could be significant as therapies allowing the improvement of dyspnea in patients with ILD are scarce.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
- Diagnosis of interstitial lung disease, based on the results of a multidisciplinary diagnosis discussion.
- Restrictive ventilatory defect (i.e. total lung capacity (TLC) < 80% of predicted value) on pulmonary function testing.
- Active cancer
- History of severe heart disease
- Neurological or orthopaedic problem that could interfere with exercise performance
- Physiological mixed syndromes (i.e. concomitant restrictive and obstructive defects)
- Exacerbation of disease or hospitalisation in the last 4 weeks prior to enrollment
- Long-term oxygen therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Pursed lip breathing Pursed lip breathing In this arm, patients will be asked to perform a six-minute walking test while continuously using the pursed lip breathing technique.
- Primary Outcome Measures
Name Time Method Exertional dyspnea On the day of randomization Patient-reported dyspnea will be measured using the Borg scale
- Secondary Outcome Measures
Name Time Method Six-minute walking distance On the day of randomization Oxygen uptake (ml/min) On the day of randomization, at each minute of the 6-minute walking test Non-invasive real-time measurements will be performed using a portable metabolic cart system.
Carbon dioxide output (ml/min) On the day of randomization, at each minute of the 6-minute walking test Non-invasive real-time measurements will be performed using a portable metabolic cart system.
Respiratory rate (br/min) On the day of randomization, at each minute of the 6-minute walking test Non-invasive real-time measurements will be performed using a portable metabolic cart system.
Tidal volume (ml) On the day of randomization, at each minute of the 6-minute walking test Non-invasive real-time measurements will be performed using a portable metabolic cart system.
Minute-ventilation (l/min) On the day of randomization, at each minute of the 6-minute walking test Non-invasive real-time measurements will be performed using a portable metabolic cart system.
Peripheral oxygen saturation (%) On the day of randomization, at each minute of the 6-minute walking test Non-invasive real-time measurements will be performed using a portable metabolic cart system.
Trial Locations
- Locations (1)
CHUM (Notre-Dame Hospital)
🇨🇦Montreal, Quebec, Canada