Comparative study of detailed metabolic work up evaluation in primary and recurrent renal stone formers. Is it warranted in primary stone formers and how effective will it be in the prevention of recurrent episodes?
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Blood investigations - serum creatinine, calcium, sodium, uric acid, phosphorus and total proteins.
研究概览
简要总结
The incidence of renal stone is quite high. Dietary choices are important causative factors.
The chance of recurrence after one episode of stone formation is as high as 50% in a 5 year follow up period.
The guidelines suggest detailed metabolic work up evaluation for finding the causation of stone formation in recurrent and high risk stone formers.
Recent studies have shown similar recurrence rate in primary stone formers as well.
There is a shift in the evaluation of primary stone formers. Previously, no evaluation was suggested. But now considering the risk of recurrence some form of evaluation is advocated.
This study will focus on the detailed metabolic evaluation reports in primary as well as recurrent stone formers and draw a comparison between them.
This is to identify that whether detailed metabolic evaluation is helpful in primary stone formers.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •All primary as well as recurrent stone formers aged 18-60 years who are willing to undergo detailed metabolic evaluation.
排除标准
- •Pregnant subjects
- •Infection stones
- •Chronic kidney disease (Serum creatinine >1.8 mg/dL)
- •Known metabolic disorder patients.
结局指标
主要结局
Blood investigations - serum creatinine, calcium, sodium, uric acid, phosphorus and total proteins.
时间窗: At 24 hours
24 hour urine sample for pH, calcium, sodium, chloride, uric acid, oxalate and citrate.
时间窗: At 24 hours
次要结局
- Difference in the 24 hour urine metabolic parameters between primary and recurrent stone formers(One point)