Engaging Higher-Order Mechanisms of Psychopathology: A Parsimonious Approach to Precision Medicine
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 39
- Locations
- 1
- Primary Endpoint
- Change in clinician-rated borderline personality disorder symptoms
Study Overview
Brief Summary
Participants with borderline personality disorder will undergo an a 2 - 4 week baseline assessment to determine level of outcomes of interest in the absence of treatment. After the baseline period, participants will receive six weekly 50-60-minute treatment sessions. After the 6 treatment sessions, participants will complete a 4-week follow-up period to determine the sustainability of the treatment module.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Speak English fluently
- •Diagnosis of Borderline Personality Disorder
Exclusion Criteria
- •diagnosed psychological conditions that would be better addressed by alternative treatments
- •concurrent psychotherapy
- •medication instability
- •substance use disorder
Arms & Interventions
Personality-based treatment 2 week baseline
Participants will receive treatment tailored to 1 of 3 personality dimensions after a 2 week baseline assessment
Intervention: Personality-Based Therapy (Behavioral)
Personality-based treatment 4 week baseline
Participants will receive treatment tailored to 1 of 3 personality dimensions after a 4 week baseline assessment
Intervention: Personality-Based Therapy (Behavioral)
Outcomes
Primary Outcomes
Change in clinician-rated borderline personality disorder symptoms
Time Frame: up to 14 weeks (pre-baseline, pre-intervention, post-intervention, post-follow-up)
Change in borderline personality disorder symptoms will be measured using Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) - clinician-rated version. Scores range from 0-36; higher scores indicate greater severity of borderline personality disorder symptoms
Change in patient-reported borderline personality disorder symptoms
Time Frame: weekly up to 14 weeks
Change in borderline personality disorder symptoms will be measured using Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) - self-report version. Scores range from 0-36; higher scores indicate greater severity of borderline personality disorder symptoms
Secondary Outcomes
No secondary outcomes reported
Investigators
Shannon E. Sauer-Zavala
Associate Professor
University of Kentucky