Exercise, Oxidative Stress and HIV

Completed

• Conditions: HIV Infections

• Registration Number: NCT00950937
• Lead Sponsor: Hospital de Clinicas de Porto Alegre

Brief Summary

The purpose of this study is to compare oxidative stress markers and the immunologic characteristics of HIV-infected and non-HIV subjects during a bout of moderate aerobic exercise followed by resistance exercises

Detailed Description

Not available

Study Timeline

• Study Start: 2006-06
• Primary Completion: 2007-01
• Study Completion: 2008-07
• Study First Submitted: 2009-02-16
• Results First Submitted: 2009-02-16
• Study First Submitted QC: 2009-06-25
• Results First Submitted QC: 2009-06-25
• Status Verified: 2009-08
• Study First Posted: 2009-08-03
• Results First Posted: 2009-08-03
• Last Update Submitted: 2009-08-04
• Last Update Posted: 2009-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• HIV Group:without contraindications for exercise training; to highly active antiretroviral therapy (HAART) for at least 6 months before enrollment; be classified as low level of physical activity by international physical activity questionnaire (IPAQ) and did not use antioxidant supplements.
• Control Group:negative result for HIV-1 test and the other criteria described above

Exclusion Criteria

• Subjects with previous history of cardiovascular and neurological disease, diabetes, dyslipidemia, tobacco using, physical disability and pregnant women were excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total Glutathione	3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).	The total glutathione content in erythrocyte concentrate at three moments: baseline, aerobic and resistance exercise.

Secondary Outcome Measures

Name	Time	Method
Catalase Activity	3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).	Antioxidant activity of the catalase enzyme at three moments: baseline, aerobic and exercise.
Glutathione S-transferase (GST)	3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).	Antioxidant activity of the Glutathione S-transferase enzyme at three moments: baseline, aerobic and resistance exercise.
Lipid Peroxidation	3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).	Thiobarbituric acid-reactive substances (TBARS) assay was used as an index of lipid peroxidation in erythrocytes, at three moments: baseline, aerobic and resistance exercise.
T CD4	3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).	T CD4 lymphocytes counts at three moments: baseline, aerobic and resistance exercise.
Neutrophil Count	3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).	Neutrophil count at three moments: baseline, aerobic and resistance exercise.
Peak Oxygen Uptake	1 time, before the exercise protocol	Is the maximum capacity of an individual's body to transport and utilize oxygen during incremental exercise.

Trial Locations

Locations (1)

Outpatient HIV/AIDS care unit of the Hospital de Clínicas de Porto Alegre; 🇧🇷 Porto Alegre, Rio Grande do Sul, Brazil