Ksharaplota treatment in Dushtavrana

Phase 2/3

Not yet recruiting

Conditions: Unspecified multiple injuries,

Registration Number: CTRI/2020/08/027425

Lead Sponsor: Dr Anantkumar V Shekokar

Brief Summary: *Vrana*( wound and ulcer)& process of healingis the soul of *Shalyatantra Chikitsa* (Surgical treatment ) .*Dushta Vrana* means getting vitiated by*Dosha* & hence *Dushta Vrana* or infected wound is characterized bybad smell, abnormal color with profuse discharge, severe pain and longerhealing time*.* The severity of infected wounds and their vastrange of etiologies, The treatment is cleaning & dressing the wound or it canbe more extensive. It may require surgical intervention to close the wound and stabilize the patient. *AcharyaSushruta* defines *Kshara* as the substance possessing *Ksharana*and *Kshanan* properties.

*Ksharaplota*formulation was selected and applied over the affected infected wound with thehelp of gauze piece. During the preparation of *Ksharaplota,* it is coatedwith *Snuhi kshira, Apamarga kshara & Haridra*. All these drugs are*Shodhana & Ropana*.It was observed that *Ksharaplota*has the properties as sustained release of drug, absorbs discharges, lesspainful & easily acceptable by the patient with excellent *Sodhana &Ropana* *Karma.* The clinical study has been done on 438 patients,selected randomly and divided in two groups. Group A 220 patients i.e. trial group ,were treated with localapplication of Ksharaplota . The Group B 218 patients i.e. control group, weretreated with Gold standard . The clinical assessment was done on the basis ofclinical presentation of *Dushta Vrana*,(Infectedwound) before and after the treatment.

Asgrading used for assessment of parameters which were ordinal in nature,â€œWilcoxon Signed Ranks testâ€ was used for within the group assessment (i.e.before and after treatment of a group). For between the group assessment ofparameters, Mann Whitney â€“ U test was applied. We had tested hypothesis for each parameter andresult was interpreted accordingly. The level of significance was kept at 5%(P=0.05). And the result of the present study foundsignificant .

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 435

Inclusion Criteria

in the present study dushtavrana patients will be selected from the opd /Ipd of department of shalyatantra having sign of dushtavrana upto 6 cm length and breath 6 cm over extrimities.

Exclusion Criteria

Hb% lessthan 10 gm%.Malnourish patient (as per age ,height and weightproportion.Bleeding disorder.diabetes .AIDS,Tuberculosis,Hepatitis,Malaginancy, vericose ulcer.DVT.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Efficacy of Ksharaplota in Dushtavrana (infected wound)	Efficacy of Ksharaplota in Dushtavrana (infected wound) in 4 years

Secondary Outcome Measures

Name	Time	Method
Chedana,Bhedana,Lekhana,shodhana,Ropana and wound healing properties of ksharaplota in Dushtavrana(Infected wound )	4 years

Trial Locations

Locations (1): Government Ayurved College
🇮🇳
Nanded, MAHARASHTRA, India
Government Ayurved College
🇮🇳Nanded, MAHARASHTRA, India
Dr Anantumar Shekokar
Principal investigator
dranantkumarshekokar@gmail.com