Maternal Serum Adropin as a Potential Biomarker for Placenta Accreta Spectrum
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Blood serum Adropin levels
研究概览
简要总结
Aim: To compare maternal serum adropin levels in pregnancies complicated by placenta previa and/or placenta accreta spectrum (PAS) with those of healthy pregnant women and to evaluate the diagnostic value of adropin for predicting placental invasion.
Methods:
This cross-sectional study included 84 singleton pregnancies at ≥34 weeks of gestation: 42 women diagnosed with placenta previa and/or PAS and 42 healthy pregnant women who underwent cesarean delivery. Maternal serum adropin levels are measured preoperatively using enzyme-linked immunosorbent assay. Demographic, obstetric, ultrasonographic, and intraoperative findings were recorded. Receiver operating characteristic (ROC) curve analysis is performed to assess the predictive performance of adropin for PAS.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women aged 18-45 years in the reproductive period
- •Singleton, viable third-trimester pregnancies diagnosed with placenta previa and/or PAS
排除标准
- •Uterine anomalies,
- •Chronic systemic diseases,
- •Multiple pregnancies,
- •Obstetric complications such as preterm premature rupture of membranes, threatened preterm labor, fetuses followed for intrauterine growth restriction, and placental abruption.
研究组 & 干预措施
control group
healthy pregnant women in the third trimester with similar demographic characteristics
Study group (Diagnosed with Plasenta Previa and/or Placenta accreta spectrum)
Pregnant women aged 18-45 years viable third-trimester pregnancies diagnosed with placenta previa and/or PAS (Placenta accreta spectrum)
结局指标
主要结局
Blood serum Adropin levels
时间窗: From 15.04.2024 to 01.04.2025
The aim of the present study was to evaluate maternal serum adropin levels in pregnancies complicated by placenta previa and placenta accreta spectrum and compare to healthy controls.
次要结局
未报告次要终点
研究者
Gulsum Uysal
Professor Gulsum Uysal
Adana City Training and Research Hospital