Amino Acid Supplementation in Continuous Renal Replacement Therapy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Balance of amino acids
研究概览
简要总结
ICU patients treated with continuous renal replacement therapy is recruited prior to start of treatment.
Blood samples are drawn and then dialysis start without amino acid supplementation. After a few hours samples are drawn from blood and dialysate. Then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. New samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. Then CRRT will continue with the full amino acid supplementation (standars of care).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Dialysis where amino acid supplementation is planned by treating physician
排除标准
- •Liver failure
- •Muscle disease
- •Neurodegenerative disease
研究组 & 干预措施
All patients
All patients will start CRRT treatment without amino acid supplementation After a few hours samples are drawn from blood and dialysate Patients then receive low dose of supplementation for 24 hours (33.5g, 250 ml Glavamin, Fresenius Kabi) and new samples are drawn After that patients receive full supplementation (67g, 500 ml Glavamin, Fresenius Kabi) for the rest the of CRRT treatment. After 24 hours of this treatment new samples are drawn.
干预措施: Amino acid supplementation (Glavamin, Fresenius Kabi) (Dietary Supplement)
结局指标
主要结局
Balance of amino acids
时间窗: After 3 days of dialysis
Total balance of amino acid losses and supplementation given
次要结局
- Amino acid concentration in plasma(After 3 days of dialysis)
- Concentration of vitamins and trace elements(After 3 days of dialysis)
研究者
Jonathan Grip
MD, PhD
Karolinska University Hospital