Alveolar-capillary Reserve After Exercise in COPD
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Rest-to-exercise pulmonary DTPA clearance change after exercise in COPD vs. controls
Study Overview
Brief Summary
It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass.
Detailed Description
It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass. The study participants include a control group and a group with COPD (GOLD I-III). Participants are undergoing three study days: (1) Measurement of maximal aerobic capacity and lung function test, (2) lung tissue mass and alveolar-capillary permeability is measured at rest and again 2 hours later, immediately after the participant has exercised on a bicycle ergometer and (3) supine cardiac output and pulmonary capillary blood volume will be measured at rest and immediately after exercise.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 45 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •individuals with COPD
- •Men and women
- •45-80 years old
- •COPD (GOLD stage I to III)
- •Resting arterial oxygenation > 90%
- •Inclusion criteria - healthy controls
- •Men and women
- •45-80 years old
- •Non-smokers
- •Normal lung function
- •Same sex, age (± 3 years) as the COPD group
Exclusion Criteria
- •individuals with COPD
- •Symptoms of ischemic heart disease
- •Known heart failure
- •Symptoms of illness, including fever, within 2 weeks prior to the study
- •Pregnancy
- •• Known renal or liver diseaseActive smoking (within 3 weeks)
- •Exclusion criteria - healthy controls
- •Known chronic lung disease
- •Symptoms of ischemic heart disease
- •Known heart failure
- •Symptoms of illness, including fever, within 2 weeks prior to the study
- •Pregnancy
- •Known renal or liver disease
- •Active smoking (within 3 weeks)
Arms & Interventions
Control Group
This arm consist of only healthy participants (age (+/- 3 years) and sex matched to the COPD group), which will undergo three study visits
Intervention: Acute exercise bout on visit 2 and 3 (Other)
COPD group
This arm consist of only COPD patients, which will undergo three study visits
Intervention: Acute exercise bout on visit 2 and 3 (Other)
Outcomes
Primary Outcomes
Rest-to-exercise pulmonary DTPA clearance change after exercise in COPD vs. controls
Time Frame: Measured at study day 2
The physiological change from rest to exercise in DTPA clearance
Secondary Outcomes
- Pulmonary DTPA clearance after exercise in COPD vs. controls(Measured at study day 2)
- Pulmonary DTPA clearance at rest in COPD vs. controls(Measured at study day 2)
- Rest-to-exercise change in lung tissue mass in COPD vs. controls(Measured at study day 2)
Investigators
Ronan Berg
MD, DMSc, Associate Professor
Rigshospitalet, Denmark