Integrating Tissue-based Spatial Information to Elucidate How Obesity-induced Tumour Metabolites Drive Prostate Cancer Progression
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Assess the protein expression of LDHA enzyme and MCT-1/-4 transporters in prostate carcinoma
研究概览
简要总结
Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI > 27.5) and non-severely overweight/normoweight (BMI < 27.5) patients affected by prostate carcinoma.
ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients.
iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •affected by prostate cancer
排除标准
- 未提供
结局指标
主要结局
Assess the protein expression of LDHA enzyme and MCT-1/-4 transporters in prostate carcinoma
时间窗: 4 years
次要结局
未报告次要终点
研究者
Giancarlo Albo
associate professor
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico