Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Recruiting

• Conditions: Prostate Adenocarcinoma; Prostate Neoplasm; Obesity; Prostate Cancer; Prostatic Neoplasm
• Interventions: Other: observational study

• Registration Number: NCT06292897
• Lead Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Brief Summary

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma.

ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients.

iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-20
• Status Verified: 2024-02
• Study First Submitted: 2024-02-27
• Study First Submitted QC: 2024-02-27
• Last Update Submitted: 2024-02-27
• Study First Posted: 2024-03-05
• Last Update Posted: 2024-03-05
• Primary Completion: 2026-09-15
• Study Completion: 2027-01-15

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

• affected by prostate cancer

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
obese individuals [Body Mass Index (BMI) > 30 affected by prostate cancer	observational study	-

Primary Outcome Measures

Name	Time	Method
Assess the protein expression of LDHA enzyme and MCT-1/-4 transporters in prostate carcinoma	4 years

Trial Locations

Locations (1)

IRCCS Cà Granda Ospedale Maggiore Policlinico Milano; 🇮🇹 Milan, Italy