African children’s oxygen administration and nutrition clinical trial

Not Applicable

Completed

• Conditions: Severe pneumonia; Respiratory

• Registration Number: ISRCTN10829073
• Lead Sponsor: Imperial College, London

Brief Summary

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/34734123/ (added 05/11/2021) 2024 Results article in https://doi.org/10.1016/j.eclinm.2024.102640 (added 20/05/2024) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38774673/ (added 22/05/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-06
• Study Completion: 2022-10-28
• Last Update Posted: 3 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 846

Inclusion Criteria

Children enrolled in the COAST trial (ISRCTN15622505) who survive to 48 hours and are older than 6 months

Exclusion Criteria

Children with severe malnutrition (defined as mid upper arm circumference <11.5cm)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mid-upper arm circumference (MUAC) measured by MUAC tape (supplied by UNICEF) at baseline and 90 days and/or as a composite with 90-day mortality

Secondary Outcome Measures

Name	Time	Method
Re-admission to hospital will be defined as hospitalisation