Whole Grain Job's Tear, Muscle Health, Blood Glucose and Lipid Level
- Conditions
- HyperglycemiaFrailtySarcopeniaHyperlipidemia
- Interventions
- Biological: Taiwanese whole grain job's tear (red job's tear)Biological: White job's tear
- Registration Number
- NCT06503172
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Brief Summary
Background: This investigation aims to explore efficacy of Taiwanese whole grain job's tear on muscle health and blood glucose and lipid levels in community-dwelling older adults.
Methods: An open-label, 16-week, randomized controlled, cross-over trial involving participants with subject complaint of slower gait or weakness or fall in last year were recruited. The intervention group consumed Taiwanese whole grain job's tear (red job's tear) or white job's tear. Assessments included laboratory tests, functional assessments, and body composition.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 80
People who aged 60-95 years
Patients with following characteristics:
feeling loss in activity detecting decline in self's walking speed. feeling tired of doing everything. having fall event in last year. People willing to follow the program and cooperate with us for following tracking.
People who are neither vegan nor vegetarian People agree and be able to sign the informed consent.
People with any disease affecting their limbs, including:
having fracture on limbs in the past 6 months having severe arthritis in the past 6 months any other whom PI recognized as weak control of their nervous system( e.g.: Parkinson's disease and stroke).
People with intermittent limp caused by peripheral artery diseases People with weak control of mental disorder People with weak control of Cardiopulmonary disease People with weak control of Malignant tumor People with weak control of kidney diseases (eGFR <60ml/min/1.73) People with Visual impairment and Hearing disorder which cannot help to complete the program.
People who have underwent hormone treatment and planned to undergo hormone treatment during program session.
Any other condition that PI recognized as not suitable
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Taiwanese whole grain job's tear (Red job's tear) Taiwanese whole grain job's tear (red job's tear) Taiwanese whole grain job's tear (Red job's tear) White job's tear White job's tear White job's tear Active comparator group Taiwanese whole grain job's tear (red job's tear) Active comparator group * serve as comparator group from week 0 to week 8, * assigned to red job's tear or white job's tear group from week 8 to week 16 Active comparator group White job's tear Active comparator group * serve as comparator group from week 0 to week 8, * assigned to red job's tear or white job's tear group from week 8 to week 16
- Primary Outcome Measures
Name Time Method Changes of appendicular skeletal muscle index(ASMI) 0, 8, 16 week ASMI=appendicular skeletal muscle mass(kg)/(height(m)2)
Changes of handgrip strength 0, 8, 16 week Maximal handgrip strength of dominant hand (kg)
Changes of gait speed 0, 8, 16 week Usual gait speed measured by 6-meter walking (m/s)
Changes of time required to finish timed up and go(TUG) test 0, 8, 16 week Changes of time required to finish timed up and go(TUG) test
- Secondary Outcome Measures
Name Time Method Changes of inflammation marker 0, 8, 16 week defined by hsCRP
Changes of insulin resistance 0, 8, 16 week Measured by HOMA-IR
Changes of muscle biomarker 1 0, 8 week Measured by serum myostatin
Changes of muscle biomarker 3 0, 8 week Measured by serum activin A
Changes of LDL 0, 8, 16 week Changes of LDL
Changes of muscle biomarker 2 0, 8 week Measured by serum follistatin
Trial Locations
- Locations (1)
Taipei Veterans General hospital
🇨🇳Taipei, Taiwan