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GnRH Agonist and Antagonists in an Oocyte Donation Program

Phase 4
Completed
Conditions
Effect of Two Protocols of Ovarian Stimulation on Oocyte Quality
Registration Number
NCT00505817
Lead Sponsor
Instituto Valenciano de Infertilidad, IVI VALENCIA
Brief Summary

The primary purpose of this study is to evaluate the effect of the two different protocols (long protocol vs antagonist protocol) on oocyte / embryo quality.

Detailed Description

The cycles with antagonists of the GnRHa present a series of advantages with respect the GnRHa in an oocyte donation program: treatment cycles are simpler and shorter, a lower amount of dose of gonadotrophins is needed for stimulation, and most important, a decreased rate of ovarian hyperstimulation syndrome is observed. Nevertheless, several clinical trials relate their use to a greater rate of abortion and worse oocyte/ embryo quality. In order to discriminate the endometrial factor from the quality of oocyte cohort, the best strategy is the oocyte donation model. In the present study, for the first time, the effect of different protocols (long versus antagonist protocol) will be studied in the same donor, acting as its own control, undergoing COH. We will compare the COH´s parameters and IVF outcome obtained in the same donor submitted to, firstly, GnRH antagonist protocol (Cetrorelix- n= 45) versus another consecutive cycle with long protocol (Ac. Leuprolide- n= 45).

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
Not specified
Inclusion Criteria
  • oocyte donors with age range: 18 - 34; BMI: 18 - 29 kg/m2;
Exclusion Criteria
  • PCO

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Instituto Valenciano de Infertilidad Spain

🇪🇸

Valencia, Spain

Instituto Valenciano de Infertilidad Spain
🇪🇸Valencia, Spain
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