Different Dietary Patterns

Not Applicable

Recruiting

• Conditions: Endotoxemia; Diet, Healthy
• Interventions: Other: Dietary intervention

• Registration Number: NCT06147440
• Lead Sponsor: University of Vienna

Brief Summary

The aim of the present study is to determine the effects of different standardized dietary patterns on general health markers, intestinal function, immune response and affective processes/ cognitive skills in healthy subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-10-20
• Study First Submitted: 2023-10-31
• Study First Submitted QC: 2023-11-23
• Study First Posted: 2023-11-27
• Status Verified: 2024-04
• Last Update Submitted: 2025-04-10
• Last Update Posted: 2025-04-15
• Primary Completion: 2025-10
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• BMI between 18.5 kg/m² und 24.9 kg/m²

Exclusion Criteria

• Chronic inflammatory diseases
• Metabolic diseases
• Viral or bacterial infections in the last 3 weeks
• Allergic reactions in the last 3 weeks
• Intake of anti-inflammatory drugs
• Malignant diseases
• Pregnancy and lactation
• Smoking
• Alcohol consumption > 10 g/d for women and > 20 g/d for men
• Drug consumption
• Vegetarian or vegan diet
• Food intolerances

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Dietary pattern 1	Dietary intervention	Participants receive a standardized diet following the recommendation of DACH nutrition societies.
Dietary pattern 2	Dietary intervention	Participants receive a standardized diet following the recommendation of DACH nutrition societies.

Primary Outcome Measures

Name	Time	Method
Changes in parameters of intestinal barrier function	1 week	Changes in TLR ligand serum levels

Secondary Outcome Measures

Name	Time	Method
Changes in cognitive skills	1 week	Assessment of cognitive processes using computer-based psychological tasks (Stroop effect; calculation of differences in response times to incongruent vs. congruent word-color associations)
Changes in parameters of immune response	1 week	Changes in concentration of Interleukin-6 in cell culture supernatant of stimulated immune cells
Changes in blood lipid levels	1 week	Changes in triglyceride, cholesterol levels \[mg/dl\]

Trial Locations

Locations (1)

University of Vienna; 🇦🇹 Vienna, Austria