Non-Invasive Positive Pressure Ventilation and Adult Respiratory Distress Syndrome (ARDS)
- Conditions
- Acute Respiratory Distress Syndrome
- Registration Number
- NCT00644930
- Lead Sponsor
- Eskisehir Osmangazi University
- Brief Summary
Background and objective: To determine the efficacy of non-invasive positive pressure ventilation (NPPV) and its effects upon intubation rate and mortality in ARDS.
- Detailed Description
Methods: This study was performed in the respiratory intensive care unit (ICU) at a university hospital. 20 patients who achieved the diagnostic criteria for ARDS were included. The patients were prospectively allocated into two groups: a standard therapy group and a NPPV group. Invasive mechanical ventilation indications had been determined before the study. Invasive ventilation was applied to those who in need of intubation, while those given intubation received a standard medical treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
The following criteria indicated immediate intubation was needed:
- Apne or respiratory pauses with loss of consciousness or gasping for breath or imminent respiratory arrest.
- Inability to increase the patient's PaO2 to more than 40 mmHg and SpO2 to more than 80% with a FiO2>0.6.
- Inability to increase the patient's pH levels above 7.35, and development of blurred consciousness and confusion (Glasgow Coma Scale <9) due to respiratory acidosis despite all the support given.
- Instability of the patient's hemodynamic parameters (such as systolic blood pressure <80 mmHg or heart rate <50 beats/minute lasting >1 hour despite fluid resuscitation).
Contraindications for NPPV include:
- The need for urgent intubation.
- The need for frequent aspiration due to excessive secretions (more frequent than 15 min.).
- Inability of the patient to adapt himself / herself to the device or unwillingness to undergo NPPV.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Intubation rate 48 hours
- Secondary Outcome Measures
Name Time Method Hospital mortality
Related Research Topics
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Trial Locations
- Locations (1)
Eskisehir Osmangazi University, Medical Faculty,
🇹🇷Eskisehir, Merkez, Turkey
Eskisehir Osmangazi University, Medical Faculty,🇹🇷Eskisehir, Merkez, Turkey