The Efficacy of Non-Invasive Positive Pressure Ventilation in ARDS: A Controlled Cohort Study

Eskisehir Osmangazi University1 site in 1 country20 target enrollmentAugust 2003

ConditionsAcute Respiratory Distress Syndrome

Overview

Phase: N/A
Intervention: Not specified
Conditions: Acute Respiratory Distress Syndrome
Sponsor: Eskisehir Osmangazi University
Enrollment: 20
Locations: 1
Primary Endpoint: Intubation rate
Status: Completed
Last Updated: 18 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Background and objective: To determine the efficacy of non-invasive positive pressure ventilation (NPPV) and its effects upon intubation rate and mortality in ARDS.

Detailed Description

Methods: This study was performed in the respiratory intensive care unit (ICU) at a university hospital. 20 patients who achieved the diagnostic criteria for ARDS were included. The patients were prospectively allocated into two groups: a standard therapy group and a NPPV group. Invasive mechanical ventilation indications had been determined before the study. Invasive ventilation was applied to those who in need of intubation, while those given intubation received a standard medical treatment.

Registry

clinicaltrials.gov

Start Date

August 2003

End Date

December 2007

Last Updated

18 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Eskisehir Osmangazi University

Eligibility Criteria

Inclusion Criteria

•The following criteria indicated immediate intubation was needed:
•Apne or respiratory pauses with loss of consciousness or gasping for breath or imminent respiratory arrest.
•Inability to increase the patient's PaO2 to more than 40 mmHg and SpO2 to more than 80% with a FiO2\>0.
•Inability to increase the patient's pH levels above 7.35, and development of blurred consciousness and confusion (Glasgow Coma Scale \<9) due to respiratory acidosis despite all the support given.
•Instability of the patient's hemodynamic parameters (such as systolic blood pressure \<80 mmHg or heart rate \<50 beats/minute lasting \>1 hour despite fluid resuscitation).

Exclusion Criteria

•Contraindications for NPPV include:
•The need for urgent intubation.
•The need for frequent aspiration due to excessive secretions (more frequent than 15 min.).
•Inability of the patient to adapt himself / herself to the device or unwillingness to undergo NPPV.